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Comparison of Side Effects of Morphine and Hydromorphone PCA

2014-08-27 03:42:08 | BioPortfolio

Summary

Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at our institution that hydromorphone causes less side effects but this has not been studied. We propose to treat our patients with either morphine or hydromorphone and determine how much nausea, vomiting, and itching they have with each drug

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Post Operative Pain

Intervention

Morphine PCA, Hydromorphone PCA

Location

Columbia Presbyterian Hospital
New York
New York
United States
10032

Status

Completed

Source

Columbia University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:42:08-0400

Clinical Trials [1986 Associated Clinical Trials listed on BioPortfolio]

A Study of OROS Hydromorphone HCL vs Morphine in Cancer Pain Patients.

The purpose of this study was to demonstrate the clinical equivalence of hydromorphone and morphine (immediate-release [IR] and sustained-release [SR] formulations) using the "worst pain i...

Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery

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Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain

The purpose of this research study is to determine which opiate pain medication (morphine or hydromorphone (Dilaudid)) is more effective in the treatment of acute pain in patients presenti...

Safety and Efficacy Study of Hydromorphone and Morphine

To compare a standard weight-based dose of intravenous (IV) hydromorphone (Dilaudid) to a standard weight-based dose of IV morphine in adults presenting to the ED with acute severe pain...

PubMed Articles [9950 Associated PubMed Articles listed on BioPortfolio]

Evidence for Neurotoxicity Due to Morphine or Hydromorphone in Renal Impairment: A Systematic Review.

Opioids are the mainstay of pain control for patients with chronic pain. Often, opioids with reported active metabolites, such as morphine and hydromorphone, are thought to increase the risk of neurot...

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Arthroscopic knee surgery is a common procedure and may cause enough pain to delay rehabilitation. Intra-articular (IA) morphine is a known modality for post-operative pain relief. However, the optima...

Efficacy of modified auriculotherapy for post-operative pain control in patients subjected to laparoscopic cholecystectomy.

The high frequency of post-operative pain in the patients after laparoscopic cholecystectomy has led to the need to use multiple analgesic therapies. These include auriculotherapy, although not very g...

Psychological interventions in managing post-operative pain in children: A systematic review.

Pediatric surgeries are common and painful for children. Post-operative pain is commonly managed with analgesics, however, pain is often still problematic. Despite evidence for psychological intervent...

Primary Hydromorphone-Related Intrathecal Catheter Tip Granulomas: Is There a Role for Dose and Concentration?

Intrathecal drug delivery therapy has been used effectively in treating patients with intractable chronic pain. The development of an intrathecal catheter tip granuloma (ICTG) related to delivery of i...

Medical and Biotech [MESH] Definitions

An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.

An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)

A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.

An opioid analgesic used similarly to MORPHINE in the control of moderate to severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1097)

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