Comparison Study of Operation and PEIT for Small, Solitary Hepatocellular Carcinoma (HCC)
Summary
The purpose of this study is to choose the preferred treatment modality for solitary, small hepatocellular carcinoma.
Description
To compare the below things between operation group and percutaneous ethanol injection therapy (PEIT) group:
1. Survival
- 5 year overall survival rate
- Disease free survival rate
2. Recurrence
- Cumulative recurrence rate
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Hepatocellular Carcinoma
Intervention
Operation, Percutaneous ethanol injection therapy
Location
Seoul NUH
Seoul
Chongno-gu
Korea, Republic of
110-744
Status
Recruiting
Source
Seoul National University Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00357422
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Diskectomy, Percutaneous
Percutaneous excision of a herniated or displaced intervertebral disk by posterolateral approach, always remaining outside the spinal canal. Percutaneous nucleotomy was first described by Hijikata in Japan in 1975. In 1985 Onik introduced automated percutaneous nucleotomy which consists in percutaneous aspiration of the nucleus pulposus. It is carried out under local anesthesia, thus reducing the surgical insult and requiring brief hospitalization, often performed on an outpatient basis. It appears to be a well-tolerated alternative to surgical diskectomy and chymopapain nucleolysis.
Aortography
Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.
Hepatitis B Virus, Woodchuck
An ORTHOHEPADNAVIRUS causing chronic liver disease and hepatocellular carcinoma in woodchucks. It closely resembles the human hepatitis B virus.
Hepatitis B Virus
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
Alpha-fetoproteins
The first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. They reappear in the adult serum during certain pathologic states, primarily hepatocellular carcinoma. They may also be elevated in the amniotic fluid and maternal serum during pregnancy in ANENCEPHALY.
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