Safety/Efficacy of Systane Free vs Refresh Tears
Summary
The objective of this study is to evaluate the safety and efficacy of Systane Free FID 105783 in comparison to Refresh Tears Lubricant Eye Drops (Allergan) in a specified population of dry eye patients.
Study Design
Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Conditions
Dry Eye
Intervention
Systane Free Lubricant Eye Drops
Location
El Paso Facility
El Paso
Texas
United States
79904
Status
Completed
Source
Alcon Research
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00348322
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Instillation, Drug
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from irrigation in that the irrigate is removed within minutes, but the instillate is left in place.
Mineral Oil
A mixture of liquid hydrocarbons obtained from petroleum. It is used as laxative, lubricant, ointment base, and emollient.
Petrolatum
A colloidal system of semisolid hydrocarbons obtained from PETROLEUM. It is used as an ointment base, topical protectant, and lubricant.
Free Radicals
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
Cell-free System
A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)
Clinical Trials
Fluorophotometry Evaluation of Lubricant Eye Drops
The objective of this study is to evaluate the safety and efficacy of exaggerated use of Lubricant Eye Drops in a population of normal subjects by measuring corneal epithelial permeability...
Acute Comfort and Blur of Systane Ultra and Systane
To evaluate drop comfort, acceptability, preference and blue profile between two marketed artificial tears in both dry eyes and non-dry eye patient population.
Safety/Efficacy of Systane Free vs Refresh Liquigel
The objective of this study is to evaluate the safety and efficacy of Systane Free FID 105783 in comparison to Refresh Liquigel Lubricant Eye Drops (Allergan) in a specified population of...
The Effect of Systane Ultra Lubricant Eye Drops (FID 112903) on Visual Performance
To evaluate the effect of 2 different lubricant eye drops on visual function of patients with dry eye
This is a multi-site, randomized, investigator-masked study to evaluate the physical effects of Systane(R) versus Refresh Tears(R) in subjects with moderate to severe dry eye. It is a 6-we...
PubMed Articles
Novel hydroxypropyl-guar gellable lubricant eye drops for treatment of dry eye.
OBJECTIVE|: The objective of this review is to evaluate the safety and efficacy of polyethylene glycol 400/propylene glycol/hydroxypropyl-guar (Systane(R) Ultra [PEG/PG with HP-guar], Alcon Laboratori...
Evaluation and selection of regeneration of waste lubricating oil technology.
Lubricant is one of the important resources that cannot be disposed of randomly due to the presence of pollutants. In response to economic efficiency and environmental protection, there is a growing t...
Efficacy in Patients with Dry Eye After Treatment with a New Lubricant Eye Drop Formulation.
Abstract Purpose: The effective management of dry eye must include a clinically meaningful reduction in ocular staining. Evaluations of corneal and conjunctival staining and other ocular symptoms of d...
Dexamethasone eye drops containing γ-cyclodextrin-based nanogels.
Sustained release aqueous eye drops of dexamethasone, based on cyclodextrin (CD) nanogels, were designed and tested in vivo. γCD units were cross-linked in the form of nanogels by means of an emulsif...
The synthesis of two new polyphenylene vinylene (PPV) precursor polymers which can be thermally induced to eliminate pentanol is presented. Pentanol has recently been discovered to be a very useful lu...
