Apomorphine Nasal Powder in the Treatment of Parkinson's Disease "Off" Periods.

10:26 EDT 30th May 2015 | BioPortfolio

Summary

To determine the safety and tolerability of repeated dosing with Apomorphine Nasal Powder in subjects with Parkinson's Disease.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double-Blind

Conditions

Parkinson's Disease

Intervention

Apomorphine Nasal Powder

Status

Not yet recruiting

Source

Britannia Pharmaceuticals Ltd.

Results (where available)

View Results

Links

Clinical Trials [858 Associated Clinical Trials listed on BioPortfolio]

Comparison of Continuous and Pulsatile Apomorphine in Parkinson's Disease

The purpose of this study is to compare the effects of apomorphine, given by two different methods, to determine how best to manage dyskinesias.

Low Dose Apomorphine and Parkinsonism

The purpose of this study is to determine if low doses of apomorphine worsen the motor symptoms of Parkinson's disease.

Continued Efficacy and Safety of Apomorphine in Patients With Late-Stage Parkinsons Disease

Study to measure the continued effectiveness of apomorphine after previous exposure of at least three months duration.

Long Term Safety and Efficacy of SC Apomorphine in Treatment of "Off" Episodes in Late-Stage Parkinson's Disease

The current protocol is designed to satisfy the need for a compassionate use treatment protocol as well as for a long-term open label follow-up study.

Continued Efficacy of Apomorphine After Previous Exposure of at Least Three Months

The objective of this study was to measure the continued efficacy of apomorphine after previous exposure of at least three months duration.

PubMed Articles [15805 Associated PubMed Articles listed on BioPortfolio]

Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease: A Randomized Clinical Trial.

There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Diso...

Understanding Parkinson disease: An evolving case study.

Thirty years ago, Parkinson disease was described as a shortage of the neurotransmitter dopamine. Today, understanding of this disorder includes possible genetic influences, premorbid and nonmotor iss...

Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease.

The objective of this study is to clarify the role of (G4C2)n expansions in the etiology of Parkinson disease (PD) in the worldwide multicenter Genetic Epidemiology of Parkinson's Disease (GEO-PD) coh...

Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.

Apomorphine, a subcutaneously administered drug for Parkinson's disease with short half-life requires frequent administration leading to patient non-compliance. This study aimed at synthesising and pu...

Low muscle strength in late adolescence and Parkinson disease later in life.

To evaluate maximal isometric muscle force at 18 years of age in relation to Parkinson disease (PD) later in life.

Medical and Biotech [MESH] Definitions

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

Fluid obtained by irrigation or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.

The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.

Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.

A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.

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