Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms
Summary
The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.
Description
This research study will last for three years. The first year involves a comparison of smoking cessation medications (bupropion, nicotine patch, and nicotine lozenge), including medications used in combination. The results of this study may allow researchers and clinicians to decide which medications are best for helping people to quit smoking as well as what treatments work best for different people. In addition, the first year of this study may help to clarify how these medications work.The purpose of the second and third years of this research study will be to get long-term results on the physical health, mental health, lifestyle factors, and the overall quality of life of people attempting to quit smoking. The results of this study may help researchers and clinicians better understand the health improvements that come from quitting or not quitting smoking.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Conditions
Nicotine Dependence
Intervention
nicotine patch, nicotine lozenge, nicotine patch + nicotine lozenge, bupropion, bupropion + lozenge, placebo
Location
UW-CTRI Madison Research site
Madison
Wisconsin
United States
53711
Status
Active, not recruiting
Source
National Institute on Drug Abuse (NIDA)
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00332644
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Nicotine
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Tobacco
A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.
Cotinine
The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.
Lobeline
An alkaloid that has actions similar to NICOTINE on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.
Oligohydramnios
A condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.
Clinical Trials
Smoking Cessation Intervention: Effectiveness in Primary Care
The information gathered in this study may help to develop more effective ways to help people quit smoking and stay quit in the future.
Early Effects of a New Oral Nicotine Replacement Product and NiQuitin™ Lozenge
A comparison of two products for oral nicotine replacement with respect to relief of urges to smoke after single doses of nicotine.
Innovative Interventions for Smoking Cessation
The purpose of this study is to evaluate the effect of a combination of the 21 mg nicotine patch and nicotine-free cigarette compared to 21 mg nicotine patch only and nicotine-free cigaret...
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
RATIONALE: Stop-smoking plans, including counseling and nicotine replacement therapy, may help smokers quit smoking. It is not yet known whether counseling and the nicotine lozenge is more...
Photoirritation and Photoallergic Potential of a New Nicotine Patch
An evaluation of the effects of UV exposure following the use of a new nicotine patch.
PubMed Articles
Neurosteroid allopregnanolone attenuates development of nicotine withdrawal behavior in mice.
Avoidance of the nicotine withdrawal syndrome as well as the positive subjective effects of nicotine is the major predisposing factor to motivate nicotine abuse. However, its underlying neurobehaviora...
Genome sequence of a nicotine-degrading strain of arthrobacter.
We announce a 4.63-Mb genome assembly of an isolated bacterium that is the first sequenced nicotine-degrading Arthrobacter strain. Nicotine catabolism genes of the nicotine-degrading plasmid pAO1 were...
Real-Time UV Imaging of Nicotine Release from Transdermal Patch.
PURPOSE: This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette(R) nicotine patches as a model drug delivery system. METHODS: The rat...
Nicotine has been repeatedly reported as substance possessing neuroprotective properties. This study focused on the possible beneficial effects of nicotine against the high-altitude hypoxia (9000 m fo...
Gustatory, Trigeminal, and Olfactory Aspects of Nicotine Intake in Three Mouse Strains.
Studies of nicotine consumption in rodents often intend to investigate nicotine's post-absorptive effects, yet little is known about the pre-absorptive sensory experience of nicotine drinking, includi...
