The Effect of North American Ginseng on Blood Pressure in Individuals With Hypertension
Summary
To determine the effect of North American ginseng on blood pressure in individuals with hypertension.
Description
Ginseng lacks proper clinical scrutiny for its effect on blood pressure (BP), in spite of observational evidence linking its intake to hypertension. This should be addressed considering the potential overlap between the prevalence of ginseng use and hypertension.
We undertook a single centre, randomized, controlled, double-blinded, crossover trial to determine the effect of North American ginseng (NAG) on 24-hour BP and renal function. After a 4-week placebo run-in, we randomly assigned participants to NAG or placebo treatment for 12-weeks at a dose of 3g/day. This was followed by an 8-week washout, and a subsequent 12-week period in which the opposite treatment was consumed. At run-in, and at weeks 0 and 12 of each treatment period, participants were fitted with an ambulatory BP monitor to assess 24-hour BP and serum cystatin C was measured.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Conditions
Hypertension
Intervention
North American Ginseng (Panax Quinquefolius)
Location
Risk Factor Modification Centre, St. Michael's Hospital
Toronto
Ontario
Canada
M5C 2T2
Status
Completed
Source
Risk Factor Modification Centre
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00219960
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Panax
An araliaceous genus of plants that contains a number of pharmacologically active agents used as stimulants, sedatives, and tonics, especially in traditional medicine. Sometimes confused with Siberian ginseng (ELEUTHEROCOCCUS).
Panax Notoginseng
A plant species of the genus PANAX. It contains damarane-type tetracyclic TRITERPENES. The common names of Sanchi or Tienchi are also used for Panax pseudoginseng which is distinguished in containing oleanane-type pentacyclic triterpenoids.
Indians, North American
Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.
Football
A competitive team sport played on a rectangular field. This is the American or Canadian version of the game and also includes the form known as rugby. It does not include non-North American football (= SOCCER).
Ictaluridae
A family of North American freshwater CATFISHES. It consists of four genera (Ameiurus, Ictalurus, Noturus, Pylodictis,) comprising several species, two of which are eyeless.
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