Shorter Radiation Schedule for the Treatment of Prostate Cancer

2014-08-26 22:49:41 | BioPortfolio


To improve the management of patients with early stage prostate cancer.


To compare the efficacy of a shorter radiation fractionation schedule to the prostate (5250 cGy/20 fractions over 28 days) with a conventional schedule (6600 cGy/33 fractions over 45 days) in men receiving radiotherapy for Stage T1a moderately or poorly differentiated, or T1b, T1c, or T2 prostate cancer. The primary outcome is local control in the prostate and secondary outcomes include toxicity, disease free survival, survival, quality of life and economics.

Study Design

Allocation: Randomized, Control: Dose Comparison, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Prostate Cancer


5250 cGy/20 fractions over 28 days, 6600 cGy/33 fractions over 45 days


B.C. Cancer Agency - Fraser Valley Cancer Centre
British Columbia
V3V 1Z2


Active, not recruiting


Ontario Clinical Oncology Group (OCOG)

Results (where available)

View Results


Published on BioPortfolio: 2014-08-26T22:49:41-0400

Clinical Trials [305 Associated Clinical Trials listed on BioPortfolio]

PROFIT - Prostate Fractionated Irradiation Trial

This trial is designed to determine whether an 8-week course of escalated dose conformal radiation can be compressed safely, and with similar efficacy into a 4-week course.

Feasibility Study Comparing Stereotactic Body Radiotherapy vs Conventional Palliative RT in Spinal Metastases

The purpose of this study is to obtain preliminary information that will help, in the future, design a large trial, to see if SBRT is better than CRT at controlling pain in the spine.

Palliative Radiotherapy for Bone Metastases: Single Versus Multiple Fractions.

The aim of the investigators study was to determine whether 8 Gy in a single fraction provides equivalent pain and narcotic relief compared to 30 Gy in 10 fractions for patients with painf...

Two-week Course Versus Conventionally Fractionated Chemoradiotherapy in Rectal Cancer

The investigators compare two-week course of chemoradiation (33 Gy in 10 fractions with oral capecitabine) and conventional chemoradiation (50.4 Gy in 28 fractions with 5-FU and leucovorin...

An Open-Label Study of E7974 Administered on Days 1, 8, and 15 of a 28-Day Cycle and Days 1 and 8 of a 21-Day Cycle in Patients With Solid Malignancies

The purpose of this study is to determine the maximum tolerated dose (MTD) of E7974 administered as an intravenous bolus dose on Days 1, 8, and 15 of a 28-day cycle (Arm A) or on Days 1 an...

PubMed Articles [5697 Associated PubMed Articles listed on BioPortfolio]

Stereotactic Body Radiotherapy Using a Radiobiology-Based Regimen for Stage I Non-Small-Cell Lung Cancer: Five-Year Mature Results.

Although the protocol of 48 Gy in four fractions over 4 days has been most often employed in stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer in Japan, higher doses are nec...

Effect of clay minerals and nanoparticles on chromium fractionation in soil contaminated with leather factory waste.

This study was conducted to investigate the effect of time, clay minerals and nanoparticles (NPs) on chromium (Cr) fractionation in a soil contaminated with leather factory waste (LFW). Soil was mixed...


Strongyloides venezuelensis is a parasitic nematode of rodents frequently used to obtain heterologous antigens for the immunological diagnosis of human strongyloidiasis. The aim of this study was to e...

Trypanocidal, trichomonacidal and cytotoxic components of cultivated Artemisia absinthium Linnaeus (Asteraceae) essential oil.

Artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest and it has been widely studied. The use of A. absinthium based on the collection of wild populations can result...

Particle phase distribution of polycyclic aromatic hydrocarbons in stormwater - Using humic acid and iron nano-sized colloids as test particles.

The distribution of polycyclic aromatic hydrocarbons (PAHs) in different particulate fractions in stormwater: Total, Particulate, Filtrated, Colloidal and Dissolved fractions, were examined and compar...

Medical and Biotech [MESH] Definitions

Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.

Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective antithrombotic agents. Their administration reduces the risk of hemorrhage, they have a longer half-life, and their platelet interactions are reduced in comparison to unfractionated heparin. They also provide an effective prophylaxis against postoperative major pulmonary embolism.

CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).

An ester of nicotinic acid that lowers cholesterol and triglycerides in total plasma and in the VLD- and LD-lipoprotein fractions.

Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.

More From BioPortfolio on "Shorter Radiation Schedule for the Treatment of Prostate Cancer"


Relevant Topic

Latest News Clinical Trials Research Drugs Reports Corporate
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Searches Linking to this Trial