A Human in-Vivo Model for the Detection of Inflammatory and Nociceptive Biomarkers
Summary
This study aims to establish a novel approach assisting the rational development of analgesic and anti-inflammatory drugs. In a first step we will test in healthy human volunteers whether proteins mediating inflammation and pain can be detected in an experimentally induced inflammatory skin lesion. Fluids that will be used to detect such proteins will be collected from the inflamed skin site via small porous catheters. We wish to establish the expression pattern of different proteins and correlate it with various tests assessing pain.
Study Design
Allocation: Randomized, Control: Placebo Control, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Diagnostic
Conditions
Skin Diseases
Intervention
Micro-plasmapheresis
Location
Stanford University School of Medicine
Stanford
California
United States
94305
Status
Completed
Source
Stanford University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00186563
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Plasmapheresis
Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.
Skin Diseases, Infectious
Skin diseases caused by bacteria, fungi, parasites, or viruses.
Skin Diseases, Parasitic
Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.
Skin Diseases, Viral
Skin diseases caused by viruses.
Skin Diseases, Bacterial
Skin diseases caused by bacteria.
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