Characterization of Local Vascular Effects of LNMMA

12:03 EDT 28th March 2015 | BioPortfolio

Summary

Characterization of an unexpected venodilative effect of higher L-NMMA-doses in dorsal human hand veins.

Study Design

Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Healthy Subjects

Intervention

L-NMMA(drug)

Location

Institute of Clinical Pharmacology, Medical Faculty, University of Technology
Dresden
Germany
01307

Status

Completed

Source

Dresden University of Technology

Results (where available)

View Results

Links

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Medical and Biotech [MESH] Definitions

Books intended for use in the study of specific subjects, containing systematic presentation of the principles and essential knowledge of the subjects.

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).

Studies in which a number of subjects are selected from all subjects in a defined population. Conclusions based on sample results may be attributed only to the population sampled.

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

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