Advertisement

Topics

Characterization of Local Vascular Effects of LNMMA

2014-08-27 03:50:28 | BioPortfolio

Summary

Characterization of an unexpected venodilative effect of higher L-NMMA-doses in dorsal human hand veins.

Study Design

Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Healthy Subjects

Intervention

L-NMMA(drug)

Location

Institute of Clinical Pharmacology, Medical Faculty, University of Technology
Dresden
Germany
01307

Status

Completed

Source

Dresden University of Technology

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:50:28-0400

Clinical Trials [796 Associated Clinical Trials listed on BioPortfolio]

L-NMMA Dose-response Study in Healthy Subjects

The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of ...

L-NMMA Plus Docetaxel in Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients

This is a Phase Ib study assessing the maximum tolerated dose (MTD) and dose-limiting toxicities of L-NMMA when combined with docetaxel in refractory locally advanced or metastatic triple ...

Drug-Drug Interaction Study to Assess the Effects of Multi Dose Clopidogrel on the Pharmacokinetics of Single-Dose K-877 in Healthy Adult Volunteers

The primary objective of this study is to assess the effects of clopidogrel on the PK of K-877 in healthy adult subjects.

Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole, Itraconazole, or Rifampin in Healthy Subjects

The purpose of this study is to determine the effects of concomitant administration with fluconazole, itraconazole, and rifampin on the pharmacokinetics (PK) of a single 20-mg dose of avat...

A Clinical Study to See How the Study Drug MT-4129 is Taken up by the Body in Healthy Volunteers

The purpose of this study is to investigate the safety and tolerability of ascending single and multiple oral doses of MT-4129 in healthy subjects.

PubMed Articles [14689 Associated PubMed Articles listed on BioPortfolio]

Acquisition of Conditioning between Methamphetamine and Cues in Healthy Humans.

Environmental stimuli repeatedly paired with drugs of abuse can elicit conditioned responses that are thought to promote future drug seeking. We recently showed that healthy volunteers acquired condit...

Impact of Arch Height Flexibility on Dynamic Plantar Pressure in Healthy Young Subjects with Planus Feet.

Healthy feet are important for overall health and well-being. Previous studies of older subjects showed that those with a lowered arch had an increased odds of having foot deformities, pain, and hyper...

Parkinson's Disease and Cognitive-Motor Dual-Task: Is Motor Prioritization Possible in the Early Stages of the Disease?

The authors aimed to compare the postural phase of gait initiation under single-task (gait initiation) and dual-task (gait initiation plus Stroop test) conditions in healthy subjects and in subjects w...

Patients With Coeliac Disease Reported Highter Consumption of Added Sugar and Total Fat Than Healthy Individuals.

To compare the dietary pattern between subjects with coeliac disease (CD) (cases) and subjects without (healthy controls).

Ketoconazole-Associated Liver Injury in Drug-Drug Interaction Studies in Healthy Volunteers.

Ketoconazole is a potent CYP3A inhibitor in vivo, and frequently serves as an index CYP3A inhibitor in drug-drug interaction (DDI) studies with healthy volunteers. Limitations restricting the use of s...

Medical and Biotech [MESH] Definitions

Books intended for use in the study of specific subjects, containing systematic presentation of the principles and essential knowledge of the subjects.

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).

Studies in which a number of subjects are selected from all subjects in a defined population. Conclusions based on sample results may be attributed only to the population sampled.

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

More From BioPortfolio on "Characterization of Local Vascular Effects of LNMMA"

Quick Search
Advertisement
 

Relevant Topics

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...


Searches Linking to this Trial