C-Reactive Protein as a Predictor of Stem Cell Transplant Complications
Summary
The purpose of this study is to determine if C-Reactive Protein levels are predictive for complications post transplant.
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Conditions
Cancer
Intervention
C-Reactive Protein levels
Location
Children's Memorial Hospital
Chicago
Illinois
United States
60614
Status
Completed
Source
Children's Memorial Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00179868
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
C-reactive Protein
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Tumor Suppressor Protein P53
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Wnt2 Protein
A proto-oncogene protein and member of the Wnt family of proteins. It is frequently up-regulated in human GASTRIC CANCER and is a tumor marker (TUMOR MARKERS, BIOLOGICAL) of gastric and COLORECTAL CANCER.
Seer Program
A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)
Brca1 Protein
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
Clinical Trials
C-Reactive Protein (CRP) Gene Variants and Coronary Artery Disease in a Chinese Han Population
The recognition of the association between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD) has led to an increased emphasis on CRP genetic effects on C...
This study is a, randomized, double-blind, placebo-controlled phase 2a trial evaluating the potential of MLN1202 to reduce circulating levels of C-reactive protein (CRP)in patients with ri...
Serum Total Homocysteine and C-Reactive Protein - Ancillary to IDNT
To examine the independent association of serum total homocysteine and C-reactive protein with arteriosclerotic cardiovascular disease morbidity and mortality.
C-Reactive Protein as a Predictor for Airway Hyper-Responsiveness
Background: Increased serum high sensitivity C-reactive protein (hs-CRP) has been associated with airway inflammation in asthma and may serve as a surrogate marker for the presence of airw...
Effect of Exercise on Elevated C-Reactive Protein Concentrations in Formerly Inactive Adults
The purpose of this study is to determine the effect of exercise training on elevated C-reactive protein (CRP) concentrations, an indicator of inflammation, in initially inactive women and...
PubMed Articles
Interleukin 6 and C-reactive protein in esophageal cancer.
Esophageal cancer (EC) is one of the most aggressive malignant tumors of the gastrointestinal tract. It is well known that cancer initiation and tumor development are closely linked with inflammation....
C-reactive protein and glucose regulation in familial longevity.
Earlier, we showed that the offspring from exceptionally long-lived families have a more favorable glucose metabolism when compared with controls. As chronic low-grade inflammation has been regarded a...
Background:Cancer incidence is increasing in the United Kingdom, as well as on a global basis. Biochemical parameters, such as C-reactive protein and albumin (combined to form the modified Glasgow Pro...
Exposure to certain environmental factors during childhood may influence the developing immune system, causing predisposing or protective effects toward development of autoimmune disorders. This study...
PURPOSE: This study assessed the diagnostic accuracy of C-reactive protein (CRP) after gastroesophageal cancer resection for postoperative inflammatory complications (PIC). METHODS: The clinical data...
