Immediate Treatment vs Colposcopic Follow-up for Biopsy-Proven CIN 1

2014-07-23 16:48:47 | BioPortfolio


This study looks at immediate treatment of a cervix with CIN 1 versus regular six-month follow-up with colposcopy and treatment if CIN 1 progresses.


In women who present with biopsy-proven CIN 1, to compare the management approach of regular colposcopic follow-up and only treating progressive disease using the LEEP, with an approach of immediate treatment using LEEP. The primary outcome is progression to more advanced disease (i.e., CIN 2, CIN 3 or cancer).

Study Design

Allocation: Randomized, Control: Historical Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Cervical Intraepithelial Neoplasia


loop electrosurgical excision procedure (LEEP)


Universidade Estadual de Campinas
British Columbia
CEP 13083-970




Ontario Clinical Oncology Group (OCOG)

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T16:48:47-0400

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