Low-Dose Hydrocortisone in Acutely Burned Patients

11:58 EDT 1st August 2014 | BioPortfolio

Summary

Major burns trigger the release of circulating mediators, as cytokines and endotoxin that induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to those seen in septic shock. After the initial hypovolemic phase, patients with extensive burns often present a shock with increased cardiac output and reduced systemic vascular resistances. As described in septic shock, we test the hypothesis that low-dose hydrocortisone could decrease the duration of the shock period.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double-Blind

Conditions

Burns

Intervention

hydrocortisone 200 mg/day

Location

Sylvie TISSOT
Lyon
France
69437

Status

Recruiting

Source

Hospices Civils de Lyon

Results (where available)

View Results

Links

Clinical Trials [97 Associated Clinical Trials listed on BioPortfolio]

Hydrocortisone in the Treatment of Intrusions in Patients With Posttraumatic Stress Disorder

To test overall efficacy of hydrocortisone on reexperience of traumatic memories (intrusions) and overall symptomatology in patients meeting criteria of complex chronic PTSD.

Does Concurrent Hydrocortisone With Venlafaxine XR Speed Antidepressant Response?

The primary purpose of this study is to examine whether IV hydrocortisone can speed up the time required for Venlafaxine XR to work.

Rapid Effects of Hydrocortisone on Glucose-Induced Insulin Secretion in Healthy Humans

The purpose of this study is to investigate the effect of hydrocortisone on glucose-induced insulin secretion and sensitivity, by means of an intravenous glucose tolerance test with freque...

Once-Daily Oral Modified-Release Hydrocortisone in Patients With Adrenal Insufficiency

This is a randomised, controlled, open, two-armed, two-period cross-over, multi-centre phase II/III study to assess the safety, tolerability and pharmacokinetics of once-daily oral modifie...

Hydrocortisone for Prevention of Septic Shock

Severe sepsis is a disease with a high mortality. Development of shock is a most serious complication and increases the risk of death considerably. Application of low dose hydrocortisone i...

PubMed Articles [236 Associated PubMed Articles listed on BioPortfolio]

Epidemiological trends and risk factors in major burns patients in South Korea: A 10-year experience.

To determine epidemiological trends among burns patients admitted to our burns center during 2003-2012, and the usefulness of the Abbreviated Burns Severity Index (ABSI) for predicting burns-related m...

Fludrocortisone and hydrocortisone, alone or in combination, on in vivo hemodynamics and in vitro vascular reactivity in normal and endotoxemic rats: a randomized factorial design study.

Hydrocortisone enhances the pressor response to catecholamines in healthy volunteers and septic shock patients. Similar data do not exist for fludrocortisone. We assessed the effects of single adminis...

Epidemiology and referral patterns of burns admitted to the Burns Centre at Inkosi Albert Luthuli Central Hospital, Durban.

The epidemiology, referral patterns and outcome of patients admitted to a tertiary burns unit in southern Africa were reviewed.

Hair Cortisol Measurement in Mitotane-Treated Adrenocortical Cancer Patients.

The only approved drug for the treatment of adrenocortical cancer (ACC) is mitotane. Mitotane is adrenolytic and therefore, hydrocortisone replacement therapy is necessary. Since mitotane increases co...

Interventions for treating phosphorus burns.

Phosphorus burns are rarely encountered in usual clinical practice and occur mostly in military and industrial settings. However, these burns can be fatal, even with minimal burn area, and are often a...

Medical and Biotech [MESH] Definitions

Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Burns of the respiratory tract caused by heat or inhaled chemicals.

Burns produced by contact with electric current or from a sudden discharge of electricity.

Injuries caused by electric currents. The concept excludes electric burns (BURNS, ELECTRIC), but includes accidental electrocution and electric shock.

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