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Low-Dose Hydrocortisone in Acutely Burned Patients

20:39 EDT 23rd April 2014 | BioPortfolio

Summary

Major burns trigger the release of circulating mediators, as cytokines and endotoxin that induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to those seen in septic shock. After the initial hypovolemic phase, patients with extensive burns often present a shock with increased cardiac output and reduced systemic vascular resistances. As described in septic shock, we test the hypothesis that low-dose hydrocortisone could decrease the duration of the shock period.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double-Blind

Conditions

Burns

Intervention

hydrocortisone 200 mg/day

Location

Sylvie TISSOT
Lyon
France
69437

Status

Recruiting

Source

Hospices Civils de Lyon

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Burns of the respiratory tract caused by heat or inhaled chemicals.

Burns produced by contact with electric current or from a sudden discharge of electricity.

Injuries caused by electric currents. The concept excludes electric burns (BURNS, ELECTRIC), but includes accidental electrocution and electric shock.

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