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Naltrexone in Borderline Personality Disorder

12:04 EDT 16th April 2014 | BioPortfolio

Summary

The purpose of this study is to investigate whether naltrexone reduces the intensity and duration of flashbacks and dissociative states in patients with borderline personality disorder.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Borderline Personality Disorder

Intervention

Naltrexone

Location

Dept. of Psychosomatic Medicine, Central Instiute of Mental Health
Mannheim
Baden-Würtemberg
Germany
68159

Status

Terminated

Source

Central Institute of Mental Health, Mannheim

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)

A dissociative disorder in which the individual adopts two or more distinct personalities. Each personality is a fully integrated and complex unit with memories, behavior patterns and social friendships. Transition from one personality to another is sudden.

A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)

A personality disorder characterized by the avoidance of accepting deserved blame and an unwarranted view of others as malevolent. The latter is expressed as suspiciousness, hypersensitivity, and mistrust.

A personality disorder characterized by a pervasive and excessive need to be taken care of that leads to submissive and clinging behavior and fears of separation, beginning by early adulthood and present in a variety of contexts. (From DSM-IV, 1994)

Clinical Trials [462 Associated Clinical Trials listed on BioPortfolio]

Naltrexone in the Treatment of Dissociative Symptoms in Patients With Borderline Personality Disorder

Our study aims at contributing to a valid appraisal of the magnitude of naltrexone efficacy as an antidissociative agent by using a double-blind randomized controlled trial.

Quetiapine Treatment for Symptoms Associated With Borderline Personality Disorder

Objective: The objective of this study is to quantitatively examine the efficacy of Seroquel (active ingredient quetiapine fumarate) in subjects with Borderline Personality Disorder (BPD)...

PET Imaging and Olanzapine Treatment in Borderline Personality Disorder

The overall design of the study is to perform both a PET and MRI scan on objectively identified borderline personality disorder patients, to treat them with olanzapine for 8 weeks, and to...

Effective Measurement of Risperidone Treatment Outcome for Persons With Borderline Personality Disorder

The objective of Study A is to evaluate the efficacy of risperidone on the 4 behavioral dimensions of Berderline Personality Disorder (BPD)in an open label trial:mood swings, impulsivity,...

Study of Lamotrigine Treatment of Affective Instability in Borderline Personality Disorder

This study investigates the hypothesis that instability in mood in patients with borderline personality disorder will respond the mood stabilizing medication lamotrigine.

PubMed Articles [3283 Associated PubMed Articles listed on BioPortfolio]

Co-occurrence of dissociative identity disorder and borderline personality disorder.

The literature indicates that, among individuals with borderline personality disorder, pathological dissociation correlates with a wide range of impairments and difficulties in psychological function....

Is borderline personality disorder a mood disorder?

Borderline personality disorder is by its very naming positioned as an Axis II personality disorder and thus seemingly distinct from an Axis I mood state. Clinical differentiation of those with a bord...

Identity disturbance and substance-dependence in patients with borderline personality disorder.

Identity disturbance is one of the DSM-IV criteria for borderline personality disorder, but there has been little attention to its nature. Four subsets of identity disturbance (role absorption, painfu...

Pain and pain catastrophizing among internal medicine outpatients with borderline personality symptomatology: a cross-sectional self-report survey.

Objective: The extant literature indicates that individuals with borderline personality disorder generally report higher levels of pain than individuals without this disorder. This study examined rela...

The contribution of familial internalizing and externalizing liability factors to borderline personality disorder.

Individuals with borderline personality disorder (BPD) frequently display co-morbid mental disorders. These disorders include 'internalizing' disorders (such as major depressive disorder and anxiety d...

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