YM443 in Subjects With Functional Dyspepsia
Summary
The primary objective of this study will be to characterize the dose response profile of YM443 in subjects with functional dyspepsia (FD) to enable the selection of doses for the Phase 3 clinical trial.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Conditions
Indigestion
Intervention
YM443
Location
Dr. Suresh Karne
Huntsville
Alabama
United States
35802
Status
Completed
Source
Astellas Pharma Inc
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00102310
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Lactose Intolerance
The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.
Clinical Trials
This study evaluates whether YM443 causes any changes in the electrocardiogram of healthy adults.
Inhibition of gastric acid is the key to satisfactory relief of symptoms with esomeprazole in NUD patients
PubMed Articles
Inducing indigestion: companies embrace autophagy inhibitors.
The study aimed to identify the felt common health problems, utilisation of health services and unmet needs of urban and rural elderly people of Bhaktapur district, Nepal. It was a cross sectional pop...
Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia.
Introduction: Functional dyspepsia (FD) is a highly prevalent condition with a major impact on quality of life and high socio-economic and healthcare costs. To date, no treatment of established effica...
BACKGROUND: The present study was aimed to provide ethnopharmacological basis for the medicinal use of Viola betonicifolia whole plant in indigestion and constipation. METHODS: Mice were used in in-vi...
BACKGROUND:: Heart transplantation (HTx) ameliorates the self-perceived health-related quality of life (HRQoL) of patients with terminal heart disease; gastrointestinal (GI) symptoms, due to obligator...
