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Donepezil or EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases

2014-08-27 03:54:53 | BioPortfolio

Summary

RATIONALE: Donepezil and EGb761 may be effective in improving neurocognitive function (such as thinking, attention, concentration, and memory) and may improve quality of life in patients who have undergone radiation therapy to the brain.

PURPOSE: This phase II trial is studying how well donepezil or EGb761 works in improving neurocognitive function in patients who have undergone radiation therapy for primary brain tumor or brain metastases.

Description

OBJECTIVES:

Primary

- Determine the effect of donepezil or EGb761 on neurocognitive function in patients who underwent radiotherapy for a primary brain tumor or brain metastases at least 6 months before study registration.

Secondary

- Determine the toxicity of these drugs in these patients.

- Determine the quality of life of patients treated with these drugs.

- Quantify the extent of radiation-induced white matter disease and temporal lobe atrophy in patients treated with these drugs.

OUTLINE: This is an open-label, multicenter study.

- Group 1 (closed to accrual 10/09/03): Patients receive oral donepezil once daily for 24 weeks.

- Group 2: Patients receive oral EGb761 three times daily for 24 weeks. In both groups (group 1 closed to accrual 10/09/03), treatment continues in the absence of unacceptable toxicity.

In both groups (group 1 closed to accrual 10/09/03), quality of life and neurocognitive assessment is performed at baseline and at weeks 6 (group 1 only), 12, 24, and 30.

Patients are followed at 6 weeks.

PROJECTED ACCRUAL: A total of 70 patients (35 per treatment group) will be accrued for this study within 9.5 months. (Group 1 closed to accrual 10/09/03)

Study Design

Masking: Open Label, Primary Purpose: Supportive Care

Conditions

Brain and Central Nervous System Tumors

Intervention

EGb761, donepezil hydrochloride, cognitive assessment

Location

CCOP - Western Regional, Arizona
Phoenix
Arizona
United States
85006-2726

Status

Completed

Source

Wake Forest University Baptist Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:54:53-0400

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