Screening Patients With Central Nervous System Tumors for Participation in National Cancer Institute Clinical Trials
Summary
RATIONALE: Screening tests may help doctors determine which patients are eligible for treatment on clinical trials.
PURPOSE: This clinical trial is screening patients with central nervous system tumors for participation in National Cancer Institute (NCI) clinical trials.
Description
OBJECTIVES:
- Evaluate patients with central nervous system tumors for eligibility in NCI primary clinical research protocols.
OUTLINE: Patients undergo various diagnostic procedures and clinical testing to determine eligibility for participation in NCI CNS tumor primary clinical research protocols. Patients undergo imaging scans; laboratory testing of blood, cerebrospinal fluid, bone marrow, urine, and other specimens as needed to determine protocol eligibility; and other specific organ function tests.
PROJECTED ACCRUAL: A maximum of 3,000 patients will be accrued for this study within 5 years.
Study Design
Primary Purpose: Diagnostic
Conditions
Brain and Central Nervous System Tumors
Intervention
biologic sample preservation procedure, diagnostic laboratory biomarker analysis, physiologic testing, diagnostic imaging
Location
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
Bethesda
Maryland
United States
20892-1182
Status
Recruiting
Source
National Cancer Institute (NCI)
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00040924
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Flow Injection Analysis
The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.
Biotechnology
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Laboratory Manuals
Works containing concise background information and directions for activities, including conducting experiments or diagnostic tests in the laboratory.
Point-of-care Systems
Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.
Peptide Mapping
Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.
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