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Transcranial Magnetic Stimulation in Depression

00:42 EDT 19th April 2014 | BioPortfolio

Summary

The study examines efficacy of repetitive transcranial magnetic stimulation in treating severely depressed patients who are medicated.

Description

Medicated, treatment resistant, depressed patients are randomized to active or sham repetitive transcranial magnetic stimulation (rTMS). Responding patients go into a six months follow-up period.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind, Primary Purpose: Treatment

Conditions

Depression

Intervention

repetitive transcranial magnetic stimulation

Location

VA Connecticut Healthcare System
West Haven
Connecticut
United States
06516

Status

Completed

Source

Department of Veterans Affairs

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.

A technique that involves the use of electrical coils on the head to generate a brief magnetic field which reaches the CEREBRAL CORTEX. It is coupled with ELECTROMYOGRAPHY response detection to assess cortical excitability by the threshold required to induce MOTOR EVOKED POTENTIALS. This method is also used for BRAIN MAPPING, to study NEUROPHYSIOLOGY, and as a substitute for ELECTROCONVULSIVE THERAPY for treating DEPRESSION. Induction of SEIZURES limits its clinical usage.

A persistent activity-dependent decrease in synaptic efficacy between NEURONS. It typically occurs following repeated low-frequency afferent stimulation, but it can be induced by other methods. Long-term depression appears to play a role in MEMORY.

Decompression external to the body, most often the slow lessening of external pressure on the whole body (especially in caisson workers, deep sea divers, and persons who ascend to great heights) to prevent DECOMPRESSION SICKNESS. It includes also sudden accidental decompression, but not surgical (local) decompression or decompression applied through body openings.

Depression in POSTPARTUM WOMEN, usually within four weeks after giving birth (PARTURITION). The degree of depression ranges from mild transient depression to neurotic or psychotic depressive disorders. (From DSM-IV, p386)

Clinical Trials [1160 Associated Clinical Trials listed on BioPortfolio]

Bilateral Versus Monolateral Repetitive Transcranial Stimulation in Depression

Repetitive transcranial magnetic stimulation (rTMS) has been recently FDA approved for the treatment of resistant depression. No accordance exists on which are the involved mechanisms of a...

A Clinical Trial of Magnetic Stimulation in Depression

The purpose of this study is to determine whether repetitive high field transcranial magnetic stimulation of the left or right frontal lobes is beneficial for the treatment of depression t...

Changing Thought and Action in Tobacco Dependence With Transcranial Magnetic Stimulation

This study will examine the effects of high frequency, repetitive Transcranial Magnetic Stimulation on decision-making and smoking behavior.

Long-term Bilateral Theta Burst Stimulation for the Treatment of Major Depression

Repetitive transcranial magnetic stimulation has been shown to be moderately effective in the treatment of major depression. Theta burst stimulation (TBS) is a new form of rTMS that may ex...

A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression

This is a pilot project to study if repetitive Transcranial Magnetic Stimulation (rTMS) will benefit patients with bipolar depression safely. Based on published studies, this study hypothe...

PubMed Articles [6049 Associated PubMed Articles listed on BioPortfolio]

Is transcranial magnetic stimulation effective in treatment-resistant combat related posttraumatic stress disorder?

To examine the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant posttraumatic stress disorder (PTSD) with co-occurring major depression.

Differential Effect of Conditioning Sequences in Coupling Inhibitory/Facilitatory Repetitive Transcranial Magnetic Stimulation for PostStroke Motor Recovery.

While neuromodulation through unihemispheric repetitive transcranial magnetic stimulation (rTMS) has shown promise for the motor recovery of stroke patients, the effectiveness of the coupling of diffe...

Repetitive transcranial magnetic stimulation for improving function after stroke.

It had been assumed that suppressing the undamaged contralesional motor cortex by repetitive low-frequency transcranial magnetic stimulation (rTMS) or increasing the excitability of the damaged hemisp...

Effects of Repetitive Transcranial Magnetic Stimulation on Hand Function Recovery and Excitability of the Motor Cortex After Stroke: A Meta-Analysis.

The purpose of this article was to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on hand function recovery and the plasticity of the cortex in stroke patients.

Anhedonia and Reward-Circuit Connectivity Distinguish Nonresponders from Responders to Dorsomedial Prefrontal Repetitive Transcranial Magnetic Stimulation in Major Depression.

Depression is a heterogeneous mental illness. Neurostimulation treatments, by targeting specific nodes within the brain's emotion-regulation network, may be useful both as therapies and as probes for...

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