A Study of Azithromycin in HIV-Infected Patients
Summary
To assess the dose proportionality of azithromycin concentrations and toleration when delivered in tablet formulation to HIV-infected patients.
The need exists to further assess the antibacterial agent azithromycin at differing doses in an HIV-infected population.
Description
The need exists to further assess the antibacterial agent azithromycin at differing doses in an HIV-infected population.
Patients are randomized to receive azithromycin at 1 of 2 doses in a two-treatment, two-period, cross-over study. Dosing visits are separated by at least 14-day wash-out periods.
Study Design
Intervention Model: Parallel Assignment, Primary Purpose: Treatment
Conditions
Bacterial Infections
Intervention
Azithromycin
Location
Harris Laboratories Inc
Phoenix
Arizona
United States
85040
Status
Completed
Source
NIH AIDS Clinical Trials Information Service
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00002344
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Central Nervous System Bacterial Infections
Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.
Azithromycin
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Central Nervous System Infections
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Pneumonia, Bacterial
Inflammation of the lung parenchyma that is caused by bacterial infections.
Bacterial Infections
Infections by bacteria, general or unspecified.
Clinical Trials
This study compares 2 different treatments administered to try to prevent serious bacterial infections (such as pneumonia) in HIV-positive children. A combination of drugs (azithromycin pl...
Phase I Study of the Clinical Pharmacology of Azithromycin in Buffy Coat of HIV-Infected Subjects.
To compare the uptake of azithromycin in white cells relative to plasma concentrations in HIV-infected patients.
Outpatient Registry Trial of Respiratory Tract Infections in Adults
To measure the speed of bacterial eradication from the respiratory tract after administration of azithromycin or telithromycin.
To assess effectiveness of Trulimax (Azithromycin) in Acute Bacterial Upper Respiratory Tract Infections (URTIs).
The objectives of the study were to confirm that a single, 2.0-g dose of azithromycin sustained release (SR) was at least as effective to 10 days of oral levofloxacin 500 mg once a day, wh...
PubMed Articles
Safety and effectiveness of azithromycin in the treatment of respiratory infections in children.
Abstract Objectives: To describe clinical effectiveness of azithromycin in management of respiratory tract infections in children up to 12 years old, to examine duration of symptoms after beginni...
Azithromycin 1.5% ophthalmic solution: in purulent bacterial or trachomatous conjunctivitis.
The second-generation macrolide azithromycin is available as a 1.5% ophthalmic solution for use in the treatment of bacterial or trachomatous conjunctivitis. This article reviews the pharmacological p...
Azithromycin in periodontal treatment: more than an antibiotic.
Hirsch R, Deng H, Laohachai MN. Azithromycin in periodontal treatment: more than an antibiotic. J Periodont Res 2011.doi: 10.1111/j.1600-0765.2011.01418.x.©2011 John Wiley & Sons A/S Azithromycin is...
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Respiratory disease is the main cause of morbidity and mortality in patients with cystic fibrosis (CF), In particular, patients suffer from chronic infection due biofilm formation by opportunistic Pse...
