Effects of Subanesthetic Concentrations of Nitrous Oxide - 1
Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.
Study Design
Primary Purpose: Treatment
Conditions
Opioid-Related Disorders
Intervention
Nitrous oxide
Location
University of Chicago, Anesthesia & Critical Care
Chicago
Illinois
United States
60637
Status
Completed
Source
National Institute on Drug Abuse (NIDA)
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00000249
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Opioid-related Disorders
Disorders related or resulting from abuse or mis-use of opioids.
Nitrous Oxide
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
Subacute Combined Degeneration
A neuropathy due to VITAMIN B 12 DEFICIENCY or to excessive NITROUS OXIDE inhalation. It is associated with overproduction of the myelinolytic TUMOR NECROSIS FACTOR-ALPHA.
Substance-related Disorders
Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.
Halothane
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Clinical Trials
Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abuser...
Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abuser...
Role of Instructions in Nitrous Oxide Effects and Choice - 10
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abuser...
Effects of Behavioral Contingencies on Effects of Nitrous Oxide - 12
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abuser...
Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abuser...
PubMed Articles
Is nitrous oxide use appropriate in neurosurgical and neurologically at-risk patients?
PURPOSE OF REVIEW: To address controversial issues surrounding the use of nitrous oxide as a component of anesthesia in neurosurgical and neurologically at-risk patients. RECENT FINDINGS: Nitrous oxid...
An Estimate of the Global Sink for Nitrous Oxide in Soils.
A literature survey of studies reporting nitrous oxide uptake in the soils of natural ecosystems is used to suggest that the median uptake potential is 4 μg m(-2) hr(-1) . The highest values are near...
Lack of sex differences to the subjective effects of nitrous oxide in healthy volunteers.
BACKGROUND: Although numerous studies have assessed subjective effects of nitrous oxide, few studies have analyzed for sex differences. Since sex differences have been reported in subjective effects o...
Effect of nitrous oxide on cisatracurium infusion demands: a randomized controlled trial.
ABSTRACT: BACKGROUND: Recent studies have questioned our previous understanding on the effect of nitrous oxide on muscle relaxants, since nitrous oxide has been shown to potentiate the action of bolus...
BACKGROUND: Non-medical use of prescription opioids represents a national public health concern of growing importance. Mood and anxiety disorders are highly associated with non-medical prescription op...
