IV Cocaine Abuse: A Laboratory Model - 4
Summary
The purpose of this study is to evaluate the effects of pergolide on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving in non-opiate dependent cocaine users.
Study Design
Primary Purpose: Treatment
Conditions
Cocaine-Related Disorders
Intervention
Pergolide
Location
Columbia University
New York
New York
United States
10023
Status
Completed
Source
National Institute on Drug Abuse (NIDA)
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00000215
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Cocaine-related Disorders
Disorders related or resulting from use of cocaine.
Crack Cocaine
The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. Use of crack results in alterations in function of the cardiovascular system, the autonomic nervous system, the central nervous system, and the gastrointestinal system. The slang term "crack" was derived from the crackling sound made upon igniting of this form of cocaine for smoking.
Substance-related Disorders
Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.
Opioid-related Disorders
Disorders related or resulting from abuse or mis-use of opioids.
Amphetamine-related Disorders
Disorders related or resulting from use of amphetamines.
Clinical Trials
Pergolide Treatment for Substance Abusers - 4
The purpose of this study is to evaluate the safety and efficacy of pergolide for cocaine dependence.
Dose Response Trial of Pergolide for Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and safety of pergolide for treatment of cocaine dependence.
IV Cocaine Abuse: A Laboratory Model - 3
The purpose of this study is to evaluate the effects of buprenorpine on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving in non-opiate d...
Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1
To study of classical conditioning mechanisms associated with arousal, craving and cocaine use.
Cocaine Effects in Humans: Physiology and Behavior - 1
The purpose of this study is to compare the effects of buprenorphine or methadone maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocain...
PubMed Articles
Nucleoside transporter (NT) and nucleic-related enzyme (NRE) play key roles in the physiology of nucleosides and the pharmacology of its analogs in mammals. In this study, we examined the effect of fl...
Psychostimulant abuse represents a psychiatric disorder and societal concern that has been largely unamenable to therapeutic interventions. We have previously demonstrated that the 5-HT₃ antagonist...
The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease.
One of the most widely used animal models of Parkinson's disease (PD) involves injecting 6-hydroxydopamine (6-OHDA) directly into the substantia nigra (SN). Some recent reports speculated that dopamin...
Frontal systems related symptoms in cocaine dependent patients with comorbid personality disorders.
RATIONALE: The co-occurrence of cocaine dependence and personality disorders may contribute to frontal systems-related behavioral symptoms in cocaine users. OBJECTIVE: This study aims to characterize...
Clinical Profiles, Complications, and Disability in Cocaine-Related Ischemic Stroke.
Cocaine use is associated with ischemic stroke through unique mechanisms, including reversible vasospasm, drug-induced arteritis, enhanced platelet aggregation, cardioembolism, and hypertensive surges...
