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Biomarkers in Chronic Arthritis

2016-09-21 20:23:21 | BioPortfolio

Summary

Use of genotyping for the optimization of treatment with biologics in chronic arthritis by looking for an association between certain alleles and response to treatment.

Description

Chronic arthritis in children and in adults represent a public health problem in number and difficulty of treatment. 30% of patients are non-responders and / or relapse upon discontinuation of treatment. Some of these treatments are not always well tolerated, sometimes with infectious complications including tuberculosis limiting the use of biological therapies. This study will validate a battery of genetic markers to predict responders biotherapy, determine the prognosis of patients, these treatments are reserved for the most severe forms, and thus improve the care of patients.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Chronic Arthritis

Intervention

Blood sample

Status

Completed

Source

University Hospital, Montpellier

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-09-21T20:23:21-0400

Clinical Trials [1503 Associated Clinical Trials listed on BioPortfolio]

RADAR1- Trial of a New Blood Sample Method (Remote Arthritis Disease Activity MonitoR)

It is important that patients who suffer from Rheumatoid Arthritis (RA) have their disease monitored at an early stage, as well as when it is established. Presently, if a patient is to be ...

A Comparison of the ASHC and CDSMP

The arthritis-specific Arthritis Self Help Course (ASHC) and the more generic Chronic Disease Self Management Program (CDSMP) teach generalizable skills for managing arthritis and other ch...

ARTEMIS Synovial Markers in Arthritis Childhood

The aim of this study is to find markers that could differentiate infectious and inflammatory arthritis. The investigators want to find markers by differential analysis by compare synovial...

Comparing ASHC and CDSMP Outcomes In Arthritis

The arthritis-specific Arthritis Self Help Course (ASHC) and the more generic Chronic Disease Self Management Program (CDSMP) teach generalizable skills for managing arthritis and other ch...

IL-7 and IL-7R Expression in Peripheral Blood Mononuclear Cells, Peripheral Blood Monocytes or Differentiated Macrophages of Rheumatoid Arthritis Patients With Active vs. Inactive Disease Treated With DMARD and/or CIMZIA

The purpose of the study is to better understand the factors present in the cells of inflamed joints of patients with arthritis that may cause rheumatoid arthritis. Knowledge gained from t...

PubMed Articles [19780 Associated PubMed Articles listed on BioPortfolio]

Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat.

To facilitate the development of therapies for rheumatoid arthritis (RA), the Innovative Medicines Initiative BTCure has combined the experience from several laboratories worldwide to establish a seri...

Inflammation as a Risk of Developing Chronic Kidney Disease in Rheumatoid Arthritis.

The relationship between chronic inflammation and the incidence of chronic kidney disease (CKD) remained not-clear in patients with rheumatoid arthritis (RA). This study aims to examine the relationsh...

NEVER SEEMS TO GROW PAINS: A CASE OF SUSPECTED PSEUDOSEPTIC ARTHRITIS.

Pseudoseptic arthritis is an acute inflammatory arthritis found in association with a sterile synovial fluid culture despite white blood cell (WBC) counts >100,000 and >75% polymorph neutrophils. This...

IL-9 over-expression and Th9 polarization characterize the inflamed gut, the synovial tissue and the peripheral blood of patients with psoriatic arthritis.

This study was undertaken to investigate the expression and tissue distribution of Th9 related cytokines in patients with psoriatic arthritis (PsA).

Chronic Calcium Channel Inhibitor Verapamil Antagonizes TNF-α-Mediated Inflammatory Reaction and Protects Against Inflammatory Arthritis in Mice.

It is well established that the tumor necrosis factor-α (TNF-α) plays a dominant role in rheumatoid arthritis (RA). Calcium channel is recently reported to be closely associated with various inflamm...

Medical and Biotech [MESH] Definitions

The fraction of a blood sample, following CENTRIFUGATION, that is distinguished as a thin light-colored layer between the RED BLOOD CELLS, underneath it, and the PLASMA, above it. It is composed mostly of WHITE BLOOD CELLS and PLATELETS.

The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.

The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), closely related to VISNA-MAEDI VIRUS and causing acute encephalomyelitis; chronic arthritis; PNEUMONIA; MASTITIS; and GLOMERULONEPHRITIS in goats. It is transmitted mainly in the colostrum and milk.

The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.

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