Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration

2016-09-21 20:23:22 | BioPortfolio


The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling (ASL) perfusion MR (Magnetic Resonnance) imaging, brain Near Infra-Red Spectroscopy (NIRS) and red blood cell (RBC) rheological properties.


The investigators hypothesize that brain perfusion and/or oxygenation modifications may be evidenced in SCA children who have no microarteriopathy and may correlate with hemorheological abnormalities and impaired vasomotion. A multimodal approach designed to study a. cerebral perfusion and oxygenation, b. flow motion properties and c. blood rheological parameters might help to describe the different processes involved in cerebral ischemia.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective


Sickle Cell Disease


Physical exams and blood analyzes


Centre Hospitalier Intercommunal




Imagine Institute

Results (where available)

View Results


Published on BioPortfolio: 2016-09-21T20:23:22-0400

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