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Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (13C) in Castration-Resistant Prostate Cancer

2016-09-22 20:53:27 | BioPortfolio

Summary

This is a prospective imaging study evaluating the utility of baseline metabolic MR imaging with Hyperpolarized Pyruvate (13C) as a predictive response biomarker to androgen signaling inhibition in patients with castration-resistant prostate cancer.

Description

This is a prospective imaging study evaluating the utility of baseline metabolic MR imaging as a predictive response biomarker to androgen signaling inhibition in patients with castration-resistant prostate cancer. Patients with a target lesion that is amenable for metabolic MR imaging will be eligible for study participation. Patients will undergo baseline metabolic MR imaging with Hyperpolarized Pyruvate C-13 pyruvate followed by initiation of androgen signaling inhibition (either as standard of care or as part of clinical trial; including abiraterone and/or enzalutamide treatment). Patient will subsequently undergo repeat metabolic MR scan after 28 days (+/- 7 days) of therapy. For those without primarily refractory disease, a third metabolic MR scan will be completed at the time of radiographic disease progression by PCWG2 criteria. MR- or CT-guided tumor biopsies are optional at baseline and at the time of disease progression.

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Prostate Cancer

Intervention

Pyruvate (13C), MRI

Location

University of California, San Francisco
San Francisco
California
United States
94158

Status

Active, not recruiting

Source

University of California, San Francisco

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-09-22T20:53:27-0400

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