Best Partograph Action Line to Prevent Prolonged Labour

2016-09-22 20:53:29 | BioPortfolio


Objective: To compare active labour outcomes in nulliparous women at term supervised with a partograph with the action line placed at either 2 hours or 4 hours and to determine whether the 2-hour action line placement is better for the prevention of prolonged labour.

Design: Randomised controlled trial.

Setting: A university teaching hospital in Nigeria.

Population: Nulliparous women in labour at term.

Method: Nulliparous women in labour were randomly supervised with a partograph with the action line placed at 2 hours (n=320) or 4 hours (n=320). Oxytocin augmentation, when required, was used only at the 2-hour (n=87) or 4-hour (n=61) action lines. Progress monitoring was the same in both groups.

Main outcome measure: The primary outcome measure was the prolonged labour rate. The secondary outcome measures were the mode of delivery and neonatal outcome.


Materials and methods

This prospective, randomised controlled study was conducted from April 2008 to April 2013. The labour ward staff had very good knowledge of how to use the partograph, and partographs were routinely supplied in the labour ward. The department had a management protocol for the use of the partograph for labour supervision of all parturients in labour. In addition, an audited review of how labour was managed in all parturients occurred every morning on all workdays to assess compliance with the management protocol, which ensured the continuous instruction of all staff in partograph use for labour supervision.

At the time of admission, the study participants were nulliparous, between 37 and 42 weeks gestation, in the spontaneous active phase of labour with intact fetal membranes and had singleton, cephalic-presenting fetuses. The exclusion criteria were prior antepartum haemorrhage, medical disorders in pregnancy and poor fetal growth in pregnancy. All the women who fulfilled the inclusion criteria during the antenatal period at approximately 34-36 weeks were selected, participated in an informative discussion about the study and signed a written consent. The study was approved by the UBTH research and ethics committee after a review of the study protocol and informed consent details. However, final inclusion in the study was limited to previously selected women who arrived at the labour ward at term in spontaneous active-phase labour with intact fetal membranes and still had no exclusion criteria. Upon presenting at the labour ward and being confirmed to be in active labour, the consenting women were randomised to either of two study arms: labour supervision with composite partograph action line location at 2 hours or 4 hours from the alert line by the physician but blinded to the participants. Allocation to the study arms was performed using consecutively numbered, sealed, opaque envelopes with a randomised sequence using a computer random number generator by a statistician not involved with care. A sample size determination for a 2-hour versus a 4-hour oxytocin augmentation of labour with a type 1 error (alpha) of 10% and a type II error (beta) of 20% together with a power of 80% and a level of significance of 0.05 was performed on the basis of a previous study on the effects of different partograph action lines on birth outcomes. Recruitment into each arm of the study was calculated to require 320 participants. The enrolment of women in the study was continued until a sample size of 320 was achieved in each study group, the 2-hour or 4-hour action line. There were therefore no exclusions.

Data and statistical analysis

Collected data were checked for completeness and analysed using SPSS version 17 (SPSS Inc., 233 South Wackor Drive, Chicago, Illinois 60606-6412, USA). Bivariate analyses were performed using a chi-square test for differences in proportion between the 2-hour and 4-hour lines for categorical variables, and odds ratios (ORs) and the respective confidence intervals were calculated. Continuous variables were compared using unpaired t-tests. A p-value of <0.05 was considered indicative of statistical significance.

According to the departmental protocol for spontaneous labour management, active-phase labour was defined as at least one progressive contraction at every 10-minute interval in a parturient at term with cervical os confirmed as 4cm or above. The fetal membranes were instantly ruptured at the same vaginal examination (VE), which confirmed active-phase labour in all parturients to facilitate cervical os dilatation at 1 cm per hour because intact fetal membranes cause slow labour progress during active-phase labour. Findings from admission or first VE during active labour and other feto-maternal vital signs were recorded on the partograph. The feto-maternal vital signs were subsequently recorded hourly on the partograph.

The timing of the repeat VE depended on the location of the action line on the partograph, to which the parturient was randomly allocated. For the women allocated to the 2-hour action line partograph, repeat VEs occurred every 2 hours. Women in the 4-hour group received repeat VEs every 4 hours unless the cervical os dilatation at the first VE was 7cm or above, in which case the repeat VE was performed earlier than 4 hours. The cervical os dilatations from the first and all subsequent VE findings were plotted on the partograph to show the graph of cervical os dilatation. When the cervical os dilatation progress did not cross the alert line, the progress was regarded as normal, and the subsequent care and delivery was performed by the midwife or junior obstetrics staff resident doctor. When the cervical os dilatation progress plotted on the partograph crossed the alert line, the midwife transferred the case to the obstetric team for subsequent care until delivery.

Although all the parturients were admitted to the labour ward and had their first VE conducted by a midwife and recorded on the partograph, no midwife or obstetric resident staff of a status below a senior obstetric resident was allowed to perform a VE more than twice within 2 to 4 hours on any parturient in active-phase labour. The need for a third VE by the midwife or junior obstetric staff (other than a senior resident) was considered an indication to transfer the parturient to the care of more senior obstetric staff with the skill to manage long-duration active-phase labour. This strategy ensured the involvement of the senior obstetric staff in the treatment of women who remained in active-phase labour. Oxytocin augmentation as a treatment for slow labour progress was instituted only when the 2-hour or 4-hour action line was crossed, not by the quality or frequency of uterine contractions as assessed by any method. The oxytocin base mixture and titration regimen in this study was as by the departmental protocol.

A parturient on oxytocin labour augmentation was assigned a midwife to act as companion and to monitor the infusion regimen. The maximum duration of oxytocin augmentation was 8hours in the absence of fetal distress. When augmentation had occurred for over 4 hours, the senior obstetric resident managing the case was required to inform the consultant on call duty, who was also required to be involved in all caesarean delivery-related decisions for any parturient in labour, especially if there had been augmentation of labour. According to this protocol, the partograph in our setting was used as a tool for the deployment of the labour ward staff for the management of active-phase labour in cooperation between the midwives and obstetric staff. By this arrangement, parturients whose labour progress did not cross the alert line were managed and delivered by the midwives, while the parturients whose labour progress crossed the action line were passed to the care of the more senior and experienced obstetric staff for effective and efficient labour care. Prolonged labour, as defined by the departmental protocol and in this study, was defined as an active-phase labour duration of over 12 hours.

The third stage of labour was actively managed to minimise blood loss. On the first day post-delivery, women who had vaginal delivery were interviewed using the likert scale score model regarding their satisfaction with the intervention based on the partograph action line placement and analysis was by one of the authors who was blinded to the action line placement. Those who delivered by c/s had their interview conducted on the third day post-delivery.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention


Prolonged First Stage Labor - Prevention


2-hour action line on WHO modified partograph, Oxytocin, Forewater amniotomy, 4-hour action line on WHO modified partograph




University of Benin

Results (where available)

View Results


Published on BioPortfolio: 2016-09-22T20:53:29-0400

Clinical Trials [784 Associated Clinical Trials listed on BioPortfolio]

Labor Scale Versus WHO Partograph in the Management of Labor

This study aims to compare the novel labour scale with the traditional WHO partograph in the management of spontaneous labour in primigravida in terms of maternal and neonatal outcomes

Paperless Partograph for Management of Low Risk Labor

Paperless partograph is a technique used for monitoring the progress of labor before delivery, and arriving at the accurate time to intervene for ensuring a safe delivery. The study will ...

Early Amniotomy After Vaginal Prostaglandin E2 for Induction of Labor at Term: a Randomized Clinical Trial

This study evaluates the effectiveness and safety of early amniotomy after vaginal prostaglandin E2 for induction of labor at term. Early amniotomy will be done in the early active phase o...

The Efficacy of Early Amniotomy for Induction of Labor

The purpose of this clinical trial is to investigate the efficacy of early amniotomy on reducing both the duration of labor and the frequency of dystocia in nulliparous women undergoing an...

Effects of Intranasal Administration of Oxytocin in Adults With Prader-Willi Syndrome

The investigator thinks that the oxytocin (OT) can improve durably and significantly the behavior disorders and thus the socialization but also the satisfaction and could thus be an intere...

PubMed Articles [11067 Associated PubMed Articles listed on BioPortfolio]

Oxytocin Modulation of Neural Circuits for Social Behavior.

Oxytocin is a hypothalamic neuropeptide that has gained attention for the effects on social behavior. Recent findings shed new light on the mechanisms of oxytocin in synaptic plasticity and adaptively...

Your word is my command: Oxytocin facilitates the understanding of appeal in verbal communication.

The hormone oxytocin is known to facilitate positive communication behaviors. In the current study, we aimed to examine how it affects the interpretation of verbal information during communication. We...

The Effect of Oxytocin on Social and Non-Social Behaviour and Striatal Protein Expression in C57BL/6N Mice.

Oxytocin has been suggested as a promising new treatment for neurodevelopmental disorders. However, important gaps remain in our understanding of its mode of action, in particular, to what extent oxyt...

The Effect of Extracellular Calcium on Oxytocin-Induced Contractility in Naive and Oxytocin-Pretreated Human Myometrium In Vitro.

Prolonged exposure to oxytocin during augmentation of labor is a significant risk factor for uterine atony, resulting in the desensitization phenomenon, a decrease in the responsiveness of myometrium ...

Boosting recovery rather than buffering reactivity: Higher stress-induced oxytocin secretion is associated with increased cortisol reactivity and faster vagal recovery after acute psychosocial stress.

Animal models and human studies using paradigms designed to stimulate endogenous oxytocin release suggest a stress-buffering role of oxytocin. We here examined the involvement of stress-induced periph...

Medical and Biotech [MESH] Definitions

Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.

A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.

Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).

Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).

The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed)

More From BioPortfolio on "Best Partograph Action Line to Prevent Prolonged Labour"

Quick Search

Relevant Topics

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Searches Linking to this Trial