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Impact of Metformin on In Vitro Fertilization Outcomes in Overweight and Obese PCOS Women

2016-09-22 21:08:21 | BioPortfolio

Summary

a quasi-experimental study to investigate whether metformin co-treatment would improve IVF outcomes in overweight and obese women with PCOS.

Description

This was non randomized prospective controlled "metformin-free group" study that took place in a University IVF Center. The study included fifty-one overweight and obese women (BMI>25) with PCOS underwent their first fresh autologous IVF-embryo transfer cycle and agreed to take metformin during their IVF cycles "Metformin-treated group". A cross matched cohort of fifty-one cross matched PCOS women who did not agree to take the study medication was allocated to the control group "Metformin-free group". The metformin-treated group received metformin (1000 mg per day) with the start of controlled ovarian stimulation (COH) until the day of the pregnancy check. The primary outcome measures were the total number of retrieved oocytes and the live birth rate.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Polycystic Ovary Syndrome

Intervention

Metformin

Location

Assiut University
Assiut
Egypt
71515

Status

Completed

Source

Assiut University

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-09-22T21:08:21-0400

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