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An Open-Label Study Investigating MK-8931 in Participants With Mild and Moderate Hepatic Insufficiency (MK-8931-016)

2016-09-22 21:08:21 | BioPortfolio

Summary

This study consists of Part I and Part II. The purpose of Part I is to compare the plasma pharmacokinetics of verubecestat (MK-8931) following administration of a single oral dose of 40 mg MK-8931 to participants with moderate hepatic insufficiency (HI) to that of healthy matched controls. A safety and pharmacokinetic analysis will be performed in order to support the decision to continue with part II. If a decision to continue with part II is made, participants with mild HI will be enrolled to receive a single oral dose of MK-8931 40mg. If any healthy participants from Part I do not meet the matching criteria for Part II additional healthy participants will be enrolled.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Amnestic Mild Cognitive Impairment

Intervention

MK-8931

Status

Not yet recruiting

Source

Merck Sharp & Dohme Corp.

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-09-22T21:08:21-0400

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