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Efficacy of IAC Regimen in Relapsed/Refractory AML

2016-10-19 02:38:21 | BioPortfolio

Summary

In this multicenter, randomized, open-label, prospective clinical trial, a total of 60 relapsed/refractory AML patients will be randomized into 2 groups. In the experimental arm, patients receivd IAC regimen. In the control arm, patients receive other physician-directed regimen. The primary end point is complete remission.

Description

In this multicenter, randomized, open-label, prospective clinical trial, a total of 60 relapsed/refractory AML patients will be randomized into 2 groups. Patients in the IAC arm received the therapy consisting of idarubicin 10 mg/㎡/d on days 1-3, Ara-c 100mg/㎡/d on days 1-7 and CTX at a dose of 350mg/㎡/d on the second day and the fifth day. In the control arm, patients received other physician-directed regimen including FLA±G regimen, Decitabine + AA regimen or AAG regimen. All the regimen in the control arm can not contain CTX. The primary end point is complete remission. The second end points include overall survival, relapse-free survival and time to treatment failure.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Acute Myeloid Leukemia

Intervention

Idarubicin, Cytarabine, Cyclophosphamide, Induction Regimen Without Cyclophosphamide

Status

Not yet recruiting

Source

Institute of Hematology & Blood Diseases Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-10-19T02:38:21-0400

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