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The overall purpose of this study is to explore the therapeutic effect of CD123-targeted chimeric antigen receptor T(CAR-T) cells in the treatment of Myeloid Malignancies.
Great progress has been made in the treatment of relapsed and refractory B cell malignancies with CD19-targeted CAR-T cells. However, for myeloid malignancies, which has higher morbidity, trials of CAR-T is few. CD123 is expressed on most myeloid leukemia cells so it is a ideal target for CAR-T. Some researches have revealed that CD123 is a marker of leukemia stem cells, which indicates that the eradication of CD123+ cells may prevent relapse of leukemia. We design and conduct this trial to test the safety and effectiveness of CD123-targeted CAR-T.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Anti-CD123-CAR-transduced T cells
Southwest Hospital of Third Millitary Medical University
Southwest Hospital, China
Published on BioPortfolio: 2016-10-19T02:38:21-0400
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Immunological rejection of leukemia cells following bone marrow transplantation.
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