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Gypenosides Treatment for Optic Neuritis

2016-11-30 15:45:16 | BioPortfolio

Summary

The purpose of this study is to determine whether gypenosides is neuroprotective in patient with acute optic neuritis.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Optic Neuritis

Intervention

Gypenosides, Placebo

Location

The First Affiliated Hospital of Guangxi Medical University
Nanning
Guangxi
China
530021

Status

Recruiting

Source

First Affiliated Hospital of Guangxi Medical University

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-11-30T15:45:16-0500

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To assess the beneficial and adverse effects of corticosteroid treatment for optic neuritis. To determine the natural history of vision in patients who suffer optic neuritis. To identify...

Intravenous Immunoglobulin Therapy in Optic Neuritis

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Atacicept in Optic Neuritis, Phase II

This study is intended to evaluate the evaluate safety and tolerability of atacicept compared to placebo and to explore the neuroprotective effect of atacicept as assessed by Optical Coher...

PubMed Articles [1291 Associated PubMed Articles listed on BioPortfolio]

Optic Canal Decompression With Unexpected Changes in Cerebrospinal Fluid of the Optic Canal.

Optic neuritis is a common inflammatory disease of the optic nerve. And the cerebral spinal fluid (CSF) in the subarachnoid space of optic nerve is thought to be homogeneous as in spine. We report a c...

Optic neuritis in pregnancy after Tdap vaccination: Report of two cases.

Two pregnant women developed one-eye blurring vision within three weeks after Tdap vaccination. Neurophtalmologic and MR examination confirmed an unilateral optic neuritis without evidence of underlyi...

Pediatric Optic Neuritis: What Is New.

Few diseases blur the margins between their childhood and adult-onset varieties as much as optic neuritis. This report will review our state of knowledge of pediatric optic neuritis, as well as its re...

Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation.

To investigate whether the presence of the retinal degeneration 8 (rd8) mutation in C57BL/6 mice alters the phenotype of autoimmune optic neuritis (AON).

Recurrent Optic Neuritis Associated With MOG Antibody Seropositivity.

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Medical and Biotech [MESH] Definitions

Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).

A syndrome characterized by acute OPTIC NEURITIS in combination with acute MYELITIS, TRANSVERSE. Demyelinating and/or necrotizing lesions form in one or both optic nerves and in the spinal cord. The onset of optic neuritis and myelitis may be simultaneous or separated by several months. (J Neurol Neurosurg Psychiatry 1996 Apr;60(4):382-387)

Atrophy of the optic disk which may be congenital or acquired. This condition indicates a deficiency in the number of nerve fibers which arise in the RETINA and converge to form the OPTIC DISK; OPTIC NERVE; OPTIC CHIASM; and optic tracts. GLAUCOMA; ISCHEMIA; inflammation, a chronic elevation of intracranial pressure, toxins, optic nerve compression, and inherited conditions (see OPTIC ATROPHIES, HEREDITARY) are relatively common causes of this condition.

An extract of absinthium and other bitter herbs, containing 60% alcohol. Prolonged ingestion causes nervousness, convulsions, trismus, amblyopia, optic neuritis, and mental deterioration. (Dorland, 27th ed)

The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914)

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