HFNC Alone or Associated With NIV for Immunocompromized Patients Admitted to ICU for Acute Respiratory Failure

2016-12-01 16:08:21 | BioPortfolio


Acute respiratory failure is the leading cause of ICU admission of immunocompromized patients. In this subgroup of patients, the need for intubation and invasive mechanical ventilation occurs in about 50% of cases and is associated with very a high mortality rate, reaching 70% of cases. Therefore, noninvasive oxygenation strategies have been developed to avoid intubation.

More than 15 years ago, 2 trials have suggested that NIV could decrease intubation and mortality rates of immunocompromized patients as compared to standard oxygen through a mask. However these results have not been confirmed in a recent large trial.

HFNC is a recent and well-tolerated oxygenation technique. In a recent trial, HFNC alone could decrease mortality and intubation rates in patients with ARF as compared to NIV. Similar findings have been reported in a post-hoc analysis on immunocompromized patients excluding those with profound neutropenia. Likewise in a retrospective monocentric cohort of immunocompromized patients, we reported better outcomes with HFNC than with NIV.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Acute Respiratory Failure




CHU de Poitiers


Not yet recruiting


Poitiers University Hospital

Results (where available)

View Results


Published on BioPortfolio: 2016-12-01T16:08:21-0500

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Medical and Biotech [MESH] Definitions

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Respiratory retention of carbon dioxide. It may be chronic or acute.

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