A Dose Finding Study Followed by a Safety and Efficacy Study for Patients With Multiple Myeloma or Lymphoma

2016-12-01 16:08:21 | BioPortfolio


The Phase 1 portion of this study will determine the safety of TAS4464 and the most appropriate dose for patients with Multiple Myeloma or Lymphoma. The Phase 2 portion of the study will investigate the efficacy and safety of TAS4464 in patients with Multiple Myeloma or Lymphoma


Background and Rationale:

• TAS4464 is an investigational NEDD8 activating enzyme (NAE) inhibitor, a compound which may affect cancer cell growth and survival. Thus, TAS4464 may help in the treatment of cancer.

Phase 1:


- To investigate the safety and tolerability of TAS4464

- To identify a tolerated dose of TAS4464


- To investigate the preliminary efficacy of TAS4464

- To investigate the pharmacokinetics (PK) and the pharmacogenomics (PGx) of TAS4464

- To investigate the pharmacodynamics of TAS4464

Phase 2:


• To investigate the efficacy of TAS4464


• To further investigate the safety profile of TAS4464

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Multiple Myeloma


TAS4464, Intravenous (IV) Infusion


United States


Not yet recruiting


Taiho Oncology, Inc.

Results (where available)

View Results


Published on BioPortfolio: 2016-12-01T16:08:21-0500

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