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CBCT is a newer type of CT scan that researchers will use to make sure the tools used to biopsy these lesions (called a bronchoscope and a radial probe-EBUS [RP-EBUS]) are in the right location. The safety and feasibility of adding this extra scan to a standard bronchoscopy will also be studied.
If participant is eligible and agrees to take part in this study, as a part of participant's standard care, participant will have a bronchoscopy to biopsy participant's suspicious lung lesion. Participant will receive a separate consent form describing the standard bronchoscopy and its risks.
During the standard bronchoscopy, the staff will use a CBCT scan to confirm that the tips of the instruments are properly placed and can reach and sample the suspicious areas being targeted. If the instruments are not in the right position, the staff will use the CBCT images to re-position their tools, if possible.
After the samples are collected, they will be sent to the pathology laboratory at MD Anderson for testing:
- If the tests show that the lesions are not cancerous, participant will be followed by the study staff for 6 months to watch for changes to the lesion (which is normally part of standard care). This will include collecting information from participant's medical record.
- If the tests show that the lesions are cancerous, patient's participation on this research study will be over, and participant will receive standard care for this type of disease (which may include surgery, chemotherapy, and/or radiation therapy).
Length of Study Participation:
Patient's active participation in this study will be over after participant's tissue samples are collected, unless follow-up imaging scans need to be collected to check the status of the disease.
This is an investigational study. Bronchoscopy and CBCT are both FDA approved and commercially available. Both are considered standard procedures. However, the combination of using CBCT to guide bronchoscopy tools into the lung lesions is considered investigational.
Up to 20 participants will be enrolled in this study. All will take part at MD Anderson.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Malignant Neoplasm of Respiratory and Intrathoracic Organ Carcinoma
Cone Beam Computed Tomography (CBCT)
University of Texas MD Anderson Cancer Center
M.D. Anderson Cancer Center
Published on BioPortfolio: 2016-12-01T16:08:22-0500
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Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.
Modality of computed tomography in which the patient is irradiated in a spiral path around the body with a cone or pyramid-shaped beam.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Clinical Research Organization
Contract Research Organization (CRO) provide research services outsourced on a contract basis to the pharmaceutical, biotechnology, healthcare and medical device industries: biopharmaceutical development biologic assay development commercial...
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