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To investigate safety, tolerability and pharmacokinetics of C-met Kinase Inhibitor HS-10241 in Subjects With Advanced Solid Tumours that are not eligible for conventional or intensive treatment. The dose of HS-10241 will be escalated to determine the dose limiting toxicity (DLT) and the maximum tolerated dose (MTD) of HS-10241 in advanced cancer patients. At the same time, pharmacokinetic characteristics and preliminary efficacy of HS-10241 will be observed in advanced cancer patients. To determine the recommended dosage regimen for phase II.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Cancer Hospital Chinese Academy of Medical Sciences
Jiangsu Hansoh Pharmaceutical Co., Ltd.
Published on BioPortfolio: 2016-12-01T16:08:22-0500
This is a phase I open-label dose-escalating trial of HS-10241 as monotherapy in subjects with solid tumors. HS-10241 was administered as oral administration.
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