ORN Study: Curative Treatment of Osteoradionecrosis (ORN) With Hybrid Bone Substitution
Summary
The main objective of the study is the cure of osteoradionecrosis (ORN) at 12 months.
Study Design
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
MANDIBLE
Intervention
Hybrid bone substitution
Location
Nantes University Hospital
Nantes
France
44093
Status
Recruiting
Source
Nantes University Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01147315
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Fibroma, Ossifying
A benign central bone tumor, usually of the jaws (especially the mandible), composed of fibrous connective tissue within which bone is formed.
Two-hybrid System Techniques
Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.
Alveolar Bone Loss
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Temporomandibular Joint
An articulation between the condyle of the mandible and the articular tubercle of the temporal bone.
Carpal Bones
The eight bones of the wrist: SCAPHOID BONE; LUNATE BONE; TRIQUETRUM BONE; PISIFORM BONE; TRAPEZIUM BONE; TRAPEZOID BONE; CAPITATE BONE; and HAMATE BONE.
Clinical Trials
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PubMed Articles
Osteogenic Potential of Mandibular vs. Long-bone Marrow Stromal Cells.
Although fundamentally similar to other bones, the jaws demonstrate discrete responses to developmental, mechanical, and homeostatic regulatory signals. Here, we hypothesized that rat mandible . long-...
Bone tissue in different parts of the edentulous maxilla and mandible.
BACKGROUND: The composition of the fully healed edentulous ridge of the posterior maxilla was recently examined and was found to contain about 50% mineralized bone and 16% bone marrow. AIM: The object...
: Radiotherapy, a cornerstone of head and neck cancer treatment, causes substantial morbidity to normal adjoining bone. The authors assessed the radioprotective effect of amifostine therapy on the min...
Effect of Mouthguards on Head Responses and Mandible Forces in Football Helmet Impacts.
The potential for mouthguards to change the risk of concussion was studied in football helmet impacts. The Hybrid III head was modified with an articulating mandible, dentition, and compliant temporom...
Abstract The purpose of this study was to present the amount and distribution of pressure, stress, and deformation energy when basal implants in the mandible are restored with a bridge which is loaded...
