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The goal of the study is to pilot test the collection of blood samples for DNA isolation from 100 patients presenting with idiopathic calcium urolithiasis (cases) and 100 patients with negative history and radiographically-confirmed absence of urolithiasis (controls).
Idiopathic calcium oxalate urolithiasis affects 12% of men and 5% of women in the industrialized world. Familial aggregation patterns, and more recently, twin studies, have suggested a strong genetic basis. Recently, there has been an increasing appreciation of a family of anion transporters (Solute-Linked Carrier Family 26 or SLC26) with a capacity to transport oxalate. Indeed, published results from lab-based investigations support a role for variability in the activity of this family of anion transporters and level of oxalate in urine. The intriguing results from laboratory-based physiologic experiments not withstanding, to date there has been no attempt to directly evaluate the role of genetic variation in the SLC26 gene and risk of calcium oxalate urolithiasis. Motivated by this gap in the science, we ultimately seek to conduct a large, candidate gene case-control association study across two Mayo sites (Mayo Florida and Mayo Rochester).
Observational Model: Case Control, Time Perspective: Cross-Sectional
Enrolling by invitation
Published on BioPortfolio: 2015-04-22T13:35:30-0400
Kidney stones are very common. They affect 3-5% of the population in the United States. Many people are hospitalized for the treatment of kidney stones and some may die. Better understan...
The aim of this research is to use a controlled laboratory setting to determine whether bacteria isolated from kidney stones of patients play a role in the formation of non-infectious kidn...
Brushite kidney stones are a unique form of calcium phosphate stones that have a tendency to recur quickly if patients are not aggressively treated with stone prevention measures. Little r...
The aim of this research is to determine an effective antibiotic regimen following definitive surgical therapy of kidney stones caused by bacterial infection (struvite stones).
A total of 20 subjects presenting with urinary stone(s) in the kidney or ureter will be treated with an extracorporeal shockwave lithotripsy device to fragment the stones. Subjects will be...
Serum concentrations of symmetric dimethylarginine (SDMA) correlate with renal function in cats and SDMA has been shown to be a more reliable and earlier marker for chronic kidney disease (CKD) compar...
Nephrolithiasis is one of the most frequent urologic diseases. The aim of this paper is to study the composition and frequency of 8854 patient kidney stones and in a subset of them their metabolic ris...
We performed extracorporeally induced destruction of kidney stones on 72 patients. No complications have resulted from the tissue exposure to high energy shock waves. Clearance studies before and afte...
To compare percutaneous nephrolithotomy and flexible ureterorenoscopy for treating kidney stones between 2 and 3cm.
Cystinuria, a rare autosomal recessive disease characterized by a defect in cystine renal reabsorption, can often determine complex cystine renal calculi, leading to important complications such as ur...
Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.
A chronic inflammatory condition of the KIDNEY resulting in diffuse renal destruction, a grossly enlarged and nonfunctioning kidney associated with NEPHROLITHIASIS and KIDNEY STONES.
Stones in the URETER that are formed in the KIDNEY. They are rarely more than 5 mm in diameter for larger renal stones cannot enter ureters. They are often lodged at the ureteral narrowing and can cause excruciating renal colic.
A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
Formation of stones in the KIDNEY.