Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs
Summary
The purpose of this study is to define the local metabolic effects of epinephrine in the bilaterally perfused human leg.
Study Design
Allocation: Randomized, Control: Placebo Control, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Conditions
Healthy
Intervention
Epinephrine
Location
Medical research laboratories, Aarhus University Hospital
Aarhus
Denmark
8000
Status
Completed
Source
University of Aarhus
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01116609
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Metanephrine
Product of epinephrine O-methylation. It is a commonly occurring, pharmacologically and physiologically inactive metabolite of epinephrine.
Allostasis
Biological adaptation, such as the rise of EPINEPHRINE in response to exercise, stress or perceived danger, followed by a fall of epinephrine during RELAXATION. Allostasis is the achievement of stability by turning on and turning off the allostatic systems including the IMMUNE SYSTEM; the AUTONOMIC NERVOUS SYSTEM and NEUROENDOCRINE SYSTEMS.
Adrenochrome
Pigment obtained by the oxidation of epinephrine.
Tyrosine
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
Methoxyhydroxyphenylglycol
Synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover.
Clinical Trials
Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4
Epinephrine is one of the important hormones in the defense of hypoglycemia. We will test the hypothesis that antecedent hypoglycemia will blunt the metabolic, neuroendocrine and cardiova...
Pharmacokinetics (PK) Study of Epinephrine Inhalation Aerosol in Healthy Volunteers
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA-MDI (E004), in healthy male and female adult volunteers. Safety of E004 w...
Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the pr...
The Effects of Epinephrine in Endotoxemia in Normal Volunteers
Epinephrine (adrenaline) is a substance produced by the body (in the adrenal gland) in response to stress such as infection or injury. Endotoxin is a man- made substance, which causes the...
The study involves research, the purpose of which is to compare three different drug mixtures (Epinephrine, Phenylephrine 25 µg, or Phenylephrine 50 µg). Specifically, how long each med...
PubMed Articles
Emergency Treatment of Asthma.
To the Editor: In the article by Lazarus (Aug. 19 issue),(1) the author provides a comprehensive and balanced review of the emergency treatment of asthma but does not discuss the controversy around th...
Emergency Treatment of Asthma.
To the Editor: In the article by Lazarus (Aug. 19 issue),(1) the author provides a comprehensive and balanced review of the emergency treatment of asthma but does not discuss the controversy around th...
Emergency Treatment of Asthma.
To the Editor: In the article by Lazarus (Aug. 19 issue),(1) the author provides a comprehensive and balanced review of the emergency treatment of asthma but does not discuss the controversy around th...
We assessed the effect of epinephrine on human monocytes. Monocytes were isolated from 16 healthy obese and 10 lean healthy subjects. Insulin sensitivity was assessed by euglycemic hyperinsulinemic cl...
Cerebral oxygenation following epinephrine infusion.
Evidence suggests that the autonomic nervous system may actively regulate the cerebral vasculature. In this study, central hemodynamics and brain oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin...
