Relation Between Aldosterone and Cardiac Remodeling After Myocardial Infarction
Summary
to determine if the aldosteronemy proves to be predictive of a cardiac remodeling in the 6 months following a STEMI (myocardial infarction with know-shift of the segment ST) revascularized in acute phase, independently of the conventional predictive parameters (size of the infarction measured in IRM, age, HTA…).
the relation between aldosteronemy and cardiovascular events could be mainly explained by the early and long-term noxious effects of the aldosterone on cardiac remodeling
Description
After myocardial infarction, the evolution towards cardiac failure is generally related to a progressive aggravation of the cardiac dysfunction, noxious remodeling. This one depends above all on wide on the after-effects on infarction, but also on other parameters such as the age and arterial hypertension. The aldosteronemy measured as of the first hours of the infarction is associated with a bad long-term forecast. The aldosterone interacts at the same time on the mechanisms of cicatrisation and cicatricial fibrosis and on the conditions of load (volemy, vascular function). Medications anti-aldosterone can antagonise these noxious effects but they are not without adverse effects and one cannot identify the patients likely yet to really profit from it: arterial hypertension could be a prerequisite (study EPHESUS), like the attack of a critical threshold of size of the infarction (principal remodeling factor)
Study Design
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Conditions
Myocardial Infarction
Intervention
aldosteronemy determination
Location
Nancy Brabois university hospital
Vandoeuvre les Nancy
Meurthe et Moselle
France
54500
Status
Recruiting
Source
Central Hospital, Nancy, France
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01109225
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Anterior Wall Myocardial Infarction
MYOCARDIAL INFARCTION in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction.
Inferior Wall Myocardial Infarction
MYOCARDIAL INFARCTION in which the inferior wall of the heart is involved. It is often caused by occlusion of the right coronary artery.
Heart Rupture, Post-infarction
Laceration or tearing of cardiac tissues appearing after MYOCARDIAL INFARCTION.
Myocardial Bridging
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
Acute Coronary Syndrome
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode but that does not usually result in MYOCARDIAL INFARCTION.
Clinical Trials
The first aim of this study is to determine how often unrecognized myocardial infarction occur in patients using a magnetic resonance imaging (MRI) technique (known as delayed enhancement...
The study is an open, single center, observational study at the Cardiology Dept at Uppsala University Hospital. The number of patients included will be 410. The objectives are to: Evaluat...
The purpose of this study is to test whether early pre-reperfusion metoprolol administration in patients suffering and acute myocardial infarction might reduce the size of myocardial necro...
Strain-Encoded Magnetic Resonance Imaging in Acute Myocardial Infarction
The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to tr...
Myocardial Infarction Size Reduction With Atorvastatin
The purpose of this study is to determine if oral atorvastatin administered just before percutaneous coronary angioplasty for acute myocardial infarction improves early and late heart func...
PubMed Articles
Introduction: There are only very few data on gender differences in patients with ST-elevation myocardial infarction. Aim: To compare the clinical data and prognosis of patients with ST-elevation myoc...
The purpose of this study was to compare 600- and 300-mg clopidogrel loading doses in patients with ST-segment elevation myocardial infarction (STEMI).
Thirty-day rehospitalizations after acute myocardial infarction: a cohort study.
Rehospitalization is a quality-of-care indicator, yet little is known about its occurrence and predictors after myocardial infarction (MI) in the community.
Changing axis deviation and acute myocardial infarction.
Changing axis deviation has been rarely reported also during atrial fibrillation or atrial flutter. Changing axis deviation has been also rarely reported during acute myocardial infarction associated...
