Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
Summary
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or between collagen fibers using UVA light and the photo- mediator riboflavin. The purpose of this study is to generate data for presentation at medical meetings and for peer-review publication
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Conditions
Keratoconus
Location
LA Sight
Los Angeles
California
United States
Status
Recruiting
Source
Innovative Medical
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01097447
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Keratoconus
A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)
Corneal Topography
The measurement of curvature and shape of the anterior surface of the cornea using techniques such as keratometry, keratoscopy, photokeratoscopy, profile photography, computer-assisted image processing and videokeratography. This measurement is often applied in the fitting of contact lenses and in diagnosing corneal diseases or corneal changes including keratoconus, which occur after keratotomy and keratoplasty.
Clinical Trials
The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study
To describe the clinical course of keratoconus and to describe the relationships among its visual and physiological manifestations, including high- and low-contrast visual acuity, corneal...
To study the effects Intacs intracorneal ring segments(Addition Technology, Inc) insertion in the treatment of keratoconus
Corneal Crosslinking in Keratoconus and Corneal Ectasia
Prospective, randomized, single site to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes progressive keratoc...
Management of Patients With Keratoconus With Intacs
Purpose To evaluate long-term follow up of Intacs microthin prescription inserts (Addition Technology Inc, Fremont, Calif) for the management of keratoconus. Design A long-term (five year...
Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs
This study will determine the efficacy of collagen cross linking for progressive keratoconus and ectasia after lasik. It will try and determine which is a more effective treatment: collage...
PubMed Articles
Purpose: To evaluate the diagnostic capacity of the Ocular Response Analyser's keratoconus match index (KMI) and keratoconus match probability (KMP) classification in a sample of keratoconus (KC)...
Keratoconus caused by eye rubbing in patients with Tourette Syndrome.
Objective: To report the association between keratoconus and Tourette Syndrome (TS) and to reinforce that eye rubbing may be a causative factor for keratoconus.Design: Observational case series.Partic...
Corneal crosslinking for progressive keratoconus in four children.
The authors describe four children with progressive keratoconus treated by corneal crosslinking (CXL). The current CXL guidelines recommend treatment of patients 18 years and older. Nevertheless, kera...
Management of keratoconus: current scenario.
Keratoconus is an ectatic corneal dystrophy and is a leading indication for corneal transplantation surgery worldwide. The disease was first described in detail more than 150 years ago by Dr John Nott...
Corneal thickness and volume in subclinical and clinical keratoconus.
To evaluate corneal thickness and volume in subclinical and clinical keratoconus in Asian population with the aim of discriminating between normal and ectatic cornea. Eyes were placed into one of the...
