Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx
Summary
The purpose of this study is to examine disease control of contemporary oropharyngeal cancer.
As for many other primary subsites of the head and neck district, two main options have been traditionally employed for the treatment of squamous cell carcinoma of the oropharynx (ORO-SCC), surgery and radiotherapy (RT). The latter has been shown to be less 'invasive' and morbid than radical surgery and therefore has gained consensus as first line option in ORO-SCC at many Institutions across the country.
Surveillance Epidemiology and End Results (SEER) data from 1975 to 2002 show an approximate 5% to 8% improvement in 5-year overall survival for squamous head and neck cancer. Most of this improvement occurred in oropharyngeal carcinoma. Table 1 summarizes results from contemporary series using non-surgical-based approach for ORO-SCC. They consistently show that long-term locoregional control rates are in the order of 80-95%.
Study Design
Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Conditions
Squamous Cell Carcinoma of Oropharynx
Intervention
IMRT, Cisplatin, Carboplatin
Location
The Sideny Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore
Maryland
United States
21231
Status
Recruiting
Source
Sidney Kimmel Comprehensive Cancer Center
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01088802
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Carcinoma, Squamous Cell
A carcinoma derived from stratified squamous epithelium. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Carcinoma, Non-small-cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Carcinoma, Adenosquamous
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Granular Cell Tumor
Unusual tumor affecting any site of the body, but most often encountered in the head and neck. Considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. It affects women more often than men. When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
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