Study of Meniscal Allografts
Summary
Total or subtotal meniscectomies in young patients are currently responsible of pain and limitation of activities. There isn't other treatment than meniscal replacement. But there is no randomized clinical trial on meniscal allograft to validate the efficiency of this treatment.
Description
Meniscal allograft is done through United States and Europe since the last fifteen years. Operative technique has regularly improved, especially because of new arthroscopic devices. The meniscal allografts which will be used are taken on dead donors and then frozen with respect of all the reglementary aspects of tissue bank.
The graft has to be ordered as soon as the patient is randomized ; the sizing of the graft ordered is important depending on the gender size and height of the patient and on the measures of the tibial plateau on X Rays.
The arthroscopic procedure is done under general or loco-regional anesthesia. The graft has to be prepared with bone blocks attached to the anterior and posterior horn of the meniscal graft. These bone blocks will be fixed through bone tunnels and the meniscus itself will be sutured on the peripheral meniscus synovial rim.
Study Design
Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Total or Subtotal Meniscectomy Sequelae
Intervention
Meniscal Allograft, Control arm
Location
Hôpital Avicenne - Service de Chirurgie orthopédique
Bobigny
Ile de France
France
93009
Status
Not yet recruiting
Source
Assistance Publique - Hôpitaux de Paris
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01059409
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Hypophysectomy, Chemical
Total or subtotal destruction of the pituitary gland by chemical injection. It is usually achieved by injection of ethyl alcohol via trans-sphenoidal cannulation under stereotaxic control. It is usually performed for the treatment of intractable pain.
Gastrectomy
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
State Dentistry
Control, direction and financing of the total dental care of the population by a national government.
Alveolectomy
Subtotal or complete excision of the alveolar process of the maxilla or mandible. (Dorland, 28th ed)
Pyonephrosis
Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.
Clinical Trials
Background It is uncertain whether subtotal abdominal hysterectomy results in better bladder, bowel, or sexual function than total abdominal hysterectomy. Methods The invest...
Psychological Well-Being, Recovery and Sexuality After Total and Subtotal Hysterectomy
The purpose of this study is to determine whether psychological well-being, recovery and sexuality differs in women undergoing subtotal and total abdominal hysterectomy.
Chondrocyte Maturation and Cartilage Loss Following Meniscal Injury
The purpose of this study is to better understand the reason why people with injuries to their knee meniscus(cartilage) are at a higher risk for osteoarthritis later in life.
Meniscal Repair: A Randomized Prospective Trial of FAST-FIX vs. Meniscal Suturing
Meniscal repair resulting in meniscal preservation is the most desirable treatment of a torn meniscus and is one of the most commonly performed arthroscopic procedures. The inside-out men...
It has been previously demonstrated that the risk for the development of knee osteoarthritis is increased after both meniscus tear and meniscectomy. However, it is still unclear whether th...
PubMed Articles
PURPOSE: The meniscus plays an important role in the knee joint. Meniscal tears are the most common knee injuries, are seen in all age groups and have several causes. Meniscectomy and meniscal repair,...
Revision of meniscal transplants: long-term clinical follow-up.
PURPOSE: The primary aim is to document objective and subjective clinical outcome after knee arthroplasty for failed meniscal allograft transplantation; secondly, to investigate the influence of previ...
BACKGROUND: Allograft meniscal transplantation is known as a possible procedure to solve pain and loss of function in the knee of patients with a history of subtotal or total meniscectomy. PURPOSE: Th...
Proprioception following partial meniscectomy in stable knees.
PURPOSE: To investigate the proprioceptive function of patients with isolated meniscal tears of the knee before and after arthroscopic partial meniscectomy. METHODS: One hundred subjects (50 patients...
Synthetic meniscus replacement: a review.
The number of meniscus-related operations continues to rise due to the ageing and more active population. Irreparable meniscal lesions generally require (partial) meniscectomy. Although a majority of...
