APPEndicitis and Laparoscopic Criteria; APPEL Study

09:15 EST 22nd November 2014 | BioPortfolio

Summary

A diagnostic laparoscopy is frequently used to confirm the diagnosis of appendicitis. However, laparoscopic criteria for determining appendicitis are not defined. If there is any doubt about the presence of an abnormal appendix, it is usually removed. However, an appendectomy of a negative appendix has a certain morbidity and for that reason it should be avoided. The purpose of this study is to establish laparoscopic criteria for the diagnosis appendicitis during diagnostic laparoscopy.

Description

The UMCG hospital protocol of suspicion of appendicitis includes a diagnostic laparoscopy. The laparoscopic inspection of the appendix is carried out according to a specific protocol. In case of appendicitis the appendix is removed laparoscopically, a normal appendix is not removed. The primary outcome of the study is: appendicitis according to pathologic examination following appendectomy, or appendicitis according to clinical follow-up in case the appendix is not removed.

The clinical diagnosis of appendicitis in the follow-up should be confirmed radiologic examination (ultrasound, CT-scan, MRI) or by a re-operation.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Appendicitis

Location

University Medical Center Groningen
Groningen
Netherlands
9700RB

Status

Recruiting

Source

University Medical Centre Groningen

Results (where available)

View Results

Links

Clinical Trials [36 Associated Clinical Trials listed on BioPortfolio]

Appendicitis With Medical Treatment

prospective study to collect data of patients with appendicitis, not receiving operation

Study of Conservative Versus Surgical Treatment of Appendicitis

The purpose of this study is to determine if antibiotic treatment of appendicitis is an option compared to surgery. The investigators' hypothesis is that a majority of patients with append...

Emergency Department CT Scanning for Appendicitis

The purpose of this study is to compare IV contrast only vs. IV and oral contrast Computed Tomography (CT) for the diagnosis of acute appendicitis in adult patients in our emergency depart...

Appendicectomy Versus Antibiotics in the Treatment of Uncomplicated Acute Appendicitis

Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operatio...

Morphine Analgesia in Patients With Acute Appendicitis

The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.

PubMed Articles [99 Associated PubMed Articles listed on BioPortfolio]

Neutrophil-to-lymphocyte ratio as a predictor of acute appendicitis.

Accurately diagnosing appendicitis can be difficult. This retrospective study aimed to evaluate the ability of the neutrophil-to-lymphocyte ratio (NLR) to predict acute appendicitis pre-operatively an...

The importance of timely detection and management in neonatal appendicitis.

The clinical presentation of cute appendicitis is rarely encountered in neonatology. When it does occur, it is thought to be due to prematurity or develops secondary to coexisting diseases. We present...

Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis.

Delay in diagnosis and treatment of perforated appendicitis may cause life-threatening complications.The aim of this study was to determine and compare pre-operative total and direct bilirubin levels ...

Rare appendicitis-like syndrome: the case of the obstructing broccoli.

The diagnosis of acute appendicitis can be somewhat obscure in a patient that presents with right lower quadrant abdominal pain. The advancement and ease of imaging have made CT scanning readily avail...

The diagnostic value of a panel of serological markers in acute appendicitis.

Appendicitis is a frequent reason for hospital admissions. Elevated C-reactive protein, white blood cell count, and serum bilirubin have been suggested as individual markers for appendicitis and appen...

Medical and Biotech [MESH] Definitions

Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.

A genus of gram-negative, anaerobic bacteria in the family Desulfovibrionaceae. It was originally recovered from infections in patients with gangrenous and PERFORATED APPENDICITIS. It is also associated with ABSCESS; BACTEREMIA; and BILIARY TRACT sepsis.

Single or multiple areas of PUS due to bacterial infection within the hepatic parenchyma. It can be caused by a variety of BACTERIA, local or disseminated from infections elsewhere such as in APPENDICITIS; CHOLECYSTITIS; PERITONITIS; and after LIVER TRANSPLANTATION.

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