Advertisement
Advertise here Publish your press releases here Sponsor BioPortfolio
Follow us on Twitter Sign up for daily news and research emails Contributors wanted

Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells

14:28 EDT 17th April 2014 | BioPortfolio

Summary

To evaluate the efficiency of a microdevice for circulating tumor cells isolation and to correlate the circulating titre with response and progression.

Description

- Validate the clinical use of a mircofluidic device to capture circulating timor cells from a broad range of tumor types

- Characterize and identify these circulating tumor cells and demostrate cell viability with this capture method

- Apply this technology in clinically relevant settings and correlate to response to treatment and disease progression

- Elucidate predictive and pharmacodynamic biomarkers in the context of early phase trials of novel therapeutics

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Cancer

Intervention

Blood taking

Location

National Cancer Centre
Singapore
Singapore

Status

Recruiting

Source

National Cancer Centre, Singapore

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.

Skills and strategies, unrelated to the traits a test is intended to measure, that may increase test takers' scores -- may include the effects of coaching or experience in taking tests. (ERIC Thesaurus)

A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)

Unlawful act of taking property.

Clinical Trials [319 Associated Clinical Trials listed on BioPortfolio]

A Kidney Transplant Study to Look at the Effects of Taking Fixed Doses of CellCept Versus Taking Doses of CellCept Based on the Concentration of CellCept in the Blood When Taking Full or Reduced Dose Calcineurin Inhibitors

This research is being done to study the effects (good and bad) of taking CellCept based on blood concentrations versus taking a fixed dose of CellCept without measuring the blood concentr...

A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation

Anti-HIV drug therapy works best when the drugs are taken exactly as prescribed by a doctor. Because anti-HIV therapy often involves multiple drugs, some people have difficulty taking them...

Gene Expression Following Short Term Exposure to Neoadjuvant Endocrine Therapy in Invasive Breast Cancer

The purpose of this pilot study is to see if taking anastrozole (Arimidex) for 10 days causes changes in breast cancer cells. Anastrozole (Arimidex) is a drug used in the treatment of a ty...

PK of Tenofovir, Emtricitabine and Efavirenz in Healthy Volunteers

The purpose of the study is to look at the levels of three HIV medications: tenofovir, emtricitabine, and efavirenz in blood after the drug intake has been stopped in order to understand h...

Blood Vessel Function in HIV-Infected Patients Taking Anti-HIV Drugs

This is a substudy of ACTG A5142. The purpose of this substudy is to evaluate blood vessel function in HIV-infected patients taking anti-HIV drugs.

PubMed Articles [15866 Associated PubMed Articles listed on BioPortfolio]

Study of the association between blood types and breast cancer among Isfahanian women with breast cancer.

Previous studies suggest a possible association between ABO blood group and the risk of breast cancer. The aim of this study is to investigate the presence of a possible association between breast can...

Direct detection of cancer biomarkers in blood using a "place n play" modular polydimethylsiloxane pump.

Cancer biomarkers have significant potential as reliable tools for the early detection of the disease and for monitoring its recurrence. However, most current methods for biomarker detection have tech...

Cancer Incidence and Mortality in a Cohort of US Blood Donors: A 20-Year Study.

Blood donors are considered one of the healthiest populations. This study describes the epidemiology of cancer in a cohort of blood donors up to 20 years after blood donation. Records from donors who...

Assessing inequalities in preventive care use in Europe.

This paper presents new international evidence on the extent of inequalities in breast cancer screening and blood test (cholesterol and blood sugar test) in 13 European Countries using data from the 2...

Prostate biopsy sampling causes hematogenous dissemination of epithelial cellular material.

The extent of epithelial cellular material (ECM) occurring in venous blood samples after diagnostic core needle biopsy (CNB) was studied in 23 patients with CNB diagnosed prostate cancer without prova...

More From BioPortfolio on "Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells"

Search BioPortfolio:
Advertisement
Advertisement

Searches Linking to this Trial