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RCT for the Treatment of Acute Asthma in Wheezy Pre-school Aged Children

11:29 EDT 17th April 2014 | BioPortfolio

Summary

To determine if treatment of pre-school children with a history of wheeze who present to an ED with an acute wheezing episode with azithromycin for 5 days will resolve their symptoms more quickly, will require less SABA, and allow these children to remain symptom free for a longer period of time.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Asthma

Intervention

Azithromycin, Placebo

Location

Alberta Children's Hospital
Calgary
Alberta
Canada
T3B 6A8

Status

Not yet recruiting

Source

Alberta Children's Hospital

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

Drugs that are used to treat asthma.

Clinical Trials [937 Associated Clinical Trials listed on BioPortfolio]

AZISAST Study: AZIthromycin in Severe ASThma Study

The purpose of this study is to evaluate the efficacy, safety and cost-effectiveness of azithromycin as add-on therapy in adult subjects with severe persistent asthma, who remain inadequat...

ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study

The ASTHMA Pilot Study is a randomized, controlled, parallel group clinical trial of 6 weekly doses of azithromycin (cumulative dose 4800 mg) or placebo as adjunctive treatment in addition...

Childhood Asthma Research and Education (CARE) Network Trial - Montelukast or Azithromycin for Reduction of Inhaled Corticosteroids in Childhood Asthma (MARS)

The MARS trial is a randomized, double-blind, parallel group study that compares the capacity of azithromycin or montelukast to placebo as effective adjunctive therapy that allows reductio...

AZMATICS: AZithroMycin/Asthma Trial In Community Settings

The purpose of this study is to determine whether an emerging body of evidence suggests that half of adult asthma cases may be caused by chronic infection that is treatable with antibiotic...

Efficacy And Safety Of Azithromycin SR Compared With Minocycline In Acne

The primary objective is to evaluate the clinical efficacy of azithromycin microspheres treatment in outpatients with moderate to severe inflammatory acne compared with first line treatmen...

PubMed Articles [1243 Associated PubMed Articles listed on BioPortfolio]

Azithromycin inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human airway epithelial cells.

Thymic stromal lymphopoietin (TSLP) is elevated in asthma and triggers dendritic cell-mediated activation of TH2 inflammatory responses. Viral stimuli, a major cause of asthma exacerbations, have been...

Clinical Significance of Asthma Clusters by Longitudinal Analysis in Korean Asthma Cohort.

WE HAVE PREVIOUSLY IDENTIFIED FOUR DISTINCT GROUPS OF ASTHMA PATIENTS IN KOREAN COHORTS USING CLUSTER ANALYSIS: (A) smoking asthma, (B) severe obstructive asthma, (C) early-onset atopic asthma, and (D...

Azithromycin versus doxycycline for the treatment of genital chlamydia infection - a meta-analysis of randomised controlled trials.

Background. There's been recent debate questioning the efficacy of azithromycin for the treatment of urogenital chlamydia infection. We conducted a meta-analysis to compare the efficacy of 1 gram az...

Azithromycin Analog CSY0073 Attenuates Lung Inflammation induced by Lipopolysaccharide Challenge.

Azithromycin is a macrolide antibiotic with anti-inflammatory and immunomodulating effects. Long-term azithromycin therapy in patients with chronic lung diseases such as cystic fibrosis has been assoc...

Azithromycin prevents pregnancy loss: reducing the level of tumor necrosis factor-alpha and raising the level of interleukin-10 in rats.

The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, wher...

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