RCT for the Treatment of Acute Asthma in Wheezy Pre-school Aged Children
Summary
To determine if treatment of pre-school children with a history of wheeze who present to an ED with an acute wheezing episode with azithromycin for 5 days will resolve their symptoms more quickly, will require less SABA, and allow these children to remain symptom free for a longer period of time.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Asthma
Intervention
Azithromycin, Placebo
Location
Alberta Children's Hospital
Calgary
Alberta
Canada
T3B 6A8
Status
Not yet recruiting
Source
Alberta Children's Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01008761
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Azithromycin
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Therapeutic Misconception
Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.
Placebo Effect
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Asthma, Exercise-induced
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
Anti-asthmatic Agents
Drugs that are used to treat asthma.
Clinical Trials
AZISAST Study: AZIthromycin in Severe ASThma Study
The purpose of this study is to evaluate the efficacy, safety and cost-effectiveness of azithromycin as add-on therapy in adult subjects with severe persistent asthma, who remain inadequat...
ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study
The ASTHMA Pilot Study is a randomized, controlled, parallel group clinical trial of 6 weekly doses of azithromycin (cumulative dose 4800 mg) or placebo as adjunctive treatment in addition...
The MARS trial is a randomized, double-blind, parallel group study that compares the capacity of azithromycin or montelukast to placebo as effective adjunctive therapy that allows reductio...
AZMATICS: AZithroMycin/Asthma Trial In Community Settings
The purpose of this study is to determine whether an emerging body of evidence suggests that half of adult asthma cases may be caused by chronic infection that is treatable with antibiotic...
Efficacy And Safety Of Azithromycin SR Compared With Minocycline In Acne
The primary objective is to evaluate the clinical efficacy of azithromycin microspheres treatment in outpatients with moderate to severe inflammatory acne compared with first line treatmen...
PubMed Articles
Azithromycin for Prevention of Exacerbations of COPD.
Background Acute exacerbations adversely affect patients with chronic obstructive pulmonary disease (COPD). Macrolide antibiotics benefit patients with a variety of inflammatory airway diseases. Metho...
Bronchiolitis obliterans syndrome (BOS) is an important complication after hematopoietic SCT (HSCT). Recent observations suggested that azithromycin might improve lung function in BOS after HSCT. We c...
Oteo A, Herrera D, Figuero E, O'Connor A, González I, Sanz M. Azithromycin as an adjunct to scaling and root planing in the treatment of Porphyromonas gingivalis-associated periodontitis: a pilot stu...
Azithromycin in periodontal treatment: more than an antibiotic.
Hirsch R, Deng H, Laohachai MN. Azithromycin in periodontal treatment: more than an antibiotic. J Periodont Res 2011.doi: 10.1111/j.1600-0765.2011.01418.x.©2011 John Wiley & Sons A/S Azithromycin is...
Mepolizumab for severe eosinophilic asthma.
Evaluation of: Pavord ID, Korn S, Howarth P et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380(9842), 651-659 (2012). In this...
