In Situ Caries Model of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentrifrices on enamel with artificial caries lesions in an in situ model
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
675 ppmf toothpaste, Sodium Fluoride Toothpaste, Amine Fluoride Toothpaste, Sodium monofluorophosphate/Sodium Fluoride Toothpaste, Placebo
GSK Investigational Site
Results (where available)
- Source: http://clinicaltrials.gov/show/NCT01005966
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
A source of inorganic fluoride which is used topically to prevent dental caries.
A dentifrice in paste form; usually contains binder, humectant, an abrasive, a detergent, flavoring agent and often caries preventives, anti-infective agents or other medicaments.
Acidulated Phosphate Fluoride
A sodium fluoride solution, paste or powder, which has been acidulated to pH 3 to 4 and buffered with a phosphate. It is used in the prevention of dental caries.
Calcium fluoride. Occurring in nature as the mineral fluorite or fluorspar. It is the primary source of fluorine and its compounds. Pure calcium fluoride is used as a catalyst in dehydration and dehydrogenation and is used to fluoridate drinking water. (From Merck Index, 11th ed)
Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries.
This study will use an oral in situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.
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