In Situ Caries Model of Fluoride Toothpastes
Summary
This study is to evaluate the effect of fluoride dentrifrices on enamel with artificial caries lesions in an in situ model
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Conditions
Caries
Intervention
675 ppmf toothpaste, Sodium Fluoride Toothpaste, Amine Fluoride Toothpaste, Sodium monofluorophosphate/Sodium Fluoride Toothpaste, Placebo
Location
GSK Investigational Site
Indianapolis
Indiana
United States
Status
Completed
Source
GlaxoSmithKline
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01005966
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Sodium Fluoride
A source of inorganic fluoride which is used topically to prevent dental caries.
Toothpaste
A dentifrice in paste form; usually contains binder, humectant, an abrasive, a detergent, flavoring agent and often caries preventives, anti-infective agents or other medicaments.
Acidulated Phosphate Fluoride
A sodium fluoride solution, paste or powder, which has been acidulated to pH 3 to 4 and buffered with a phosphate. It is used in the prevention of dental caries.
Calcium Fluoride
Calcium fluoride. Occurring in nature as the mineral fluorite or fluorspar. It is the primary source of fluorine and its compounds. Pure calcium fluoride is used as a catalyst in dehydration and dehydrogenation and is used to fluoridate drinking water. (From Merck Index, 11th ed)
Tin Fluorides
Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries.
Clinical Trials
Enamel Remineralization Potential of Dentifrices in Situ
This study will use an oral in situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.
Evaluation of a Low-fluoride Anticaries Toothpaste
The purpose of this trial is to evaluate the anticaries remineralizing potential of a toothpaste containing 500 ppm fluoride plus fTCP technology relative to a commercially available tooth...
Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.
Clinical research study to determine the anti-plaque efficacy of prototype dentifrices via a 4-day brushing regiment
Compare the Clinical Efficacy of Prototype Toothpastes.
Evaluate clinical efficacy of a prototype toothpaste on control of dental plaque gingival inflammation
Effect of pH, Consistency and Concentration of Fluoride in Toothpaste in the Caries Control
This study aims to assess the overall effect of pH and fluoride concentration of liquid dentifrices in the control of children dental caries of a fluoridated area. Additionally,the investi...
PubMed Articles
Advertising of Toothpaste in Parenting Magazines.
We assessed advertisements for children's toothpaste in two widely read US parenting magazines. Data on the number and type of toothpaste advertisements in two parenting magazines were collected from...
Estimated dietary fluoride intake for New Zealanders.
Abstract Objectives: Existing fluoride concentration and consumption data were used to estimate fluoride intakes from the diet and toothpaste use, for New Zealand sub-populations, to identify any popu...
The Effect of Toothpaste Concentration on Enamel and Dentine Wear In Vitro.
OBJECTIVES: To determine the effect of toothpaste concentration on enamel and dentine wear in vitro and to model the effects of toothpaste abrasion upon dilution during toothbrushing in vivo. METHODS:...
BACKGROUND: NovaMin (NovaMin Technology, Alachua, Fla.) was introduced into the dental market as a desensitizer in December 2004. However, to the authors' knowledge, no researchers yet have evaluated...
Alimentary Fluoride Intake in Preschool Children.
ABSTRACT: BACKGROUND: The knowledge of background alimentary fluoride intake in preschool children is of utmost importance for introducing optimal and safe caries preventive measures for both individ...
