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Diazoxide In the Management Of Hypoglycemic Neonates

2014-07-23 21:12:29 | BioPortfolio

Summary

Diazoxide is an oral hyperglycemic medication. Diazoxide has been proven effective for treating hypoglycemia in infants and children with some types of persistent hyperinsulinemic hypoglycemia. The mechanism of action results in decreased insulin secretion. One of the causes of hypoglycemia in infants of diabetic mothers occurs due to a transient hyperinsulinemic state postnatally. The investigators have clinical experience and success using diazoxide in their unit for patients with hypoglycemia not adequately managed with intravenous (iv) dextrose and enteral supplementation. In this randomized controlled study the investigators expect that by using diazoxide as the initial treatment for infants of diabetic mothers with asymptomatic hypoglycemia (blood glucose of 2.5 to 2.0mmol/L), the investigators will be able to decrease the number of infants requiring an intravenous by at least thirty percent.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Infant, Newborn, Diseases

Intervention

Diazoxide, Ora-plus

Location

Royal University Hospital
Saskatoon
Saskatchewan
Canada
S7N 0W4

Status

Not yet recruiting

Source

University of Saskatchewan

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:12:29-0400

Clinical Trials [501 Associated Clinical Trials listed on BioPortfolio]

DZX Mediated Insulin Suppression in Obese Men

The purpose of this study is to determine whether there is an additive effect of metformine on the weight reduction of obese hyperinsulinemic men who are treated with diazoxide.

The Safety and Effectiveness of Zidovudine in HIV-Infected Pregnant Women and Their Infants

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Efficacy of Diazoxide in Type 1 Diabetes

The purpose of this study is to find out if Diazoxide can partly retain insulin production in newly diagnosed type 1 diabetes patients.

Epidemiology of Persistent Pulmonary Hypertension of the Newborn - SCOR in Lung Biology and Diseases in Infants and Children

To conduct an epidemiologic study of persistent pulmonary hypertension of the newborn ( PPHN) infant.

PubMed Articles [9941 Associated PubMed Articles listed on BioPortfolio]

Stimulation of mitochondrial ATP synthase activity - a new diazoxide-mediated mechanism of cardioprotection.

Pharmacological preconditioning by diazoxide and a model of experimental streptozotocin-induced acute diabetes mellitus (STZ-DM) provided similar levels of cardioprotection assessed as limiting myocar...

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny.

Infections in the first year of life are common and often severe. The newborn host demonstrates both quantitative and qualitative differences to the adult in nearly all aspects of immunity, which at l...

Obstetric Facility Quality and Newborn Mortality in Malawi: A Cross-Sectional Study.

Ending preventable newborn deaths is a global health priority, but efforts to improve coverage of maternal and newborn care have not yielded expected gains in infant survival in many settings. One pos...

The benefits of breastfeeding and associated risks of replacement with baby formulas.

Breastfeeding is the nourishment designed by nature for the newborn and the infant; however its prevalence is nowadays not optimal. The aim of this article is to review the current evidence of the ben...

Retrospective Typology of Paediatric Emergency Visits in One-year: Sakarya/Turkey.

Characterization of newborn (aged ≤ 28 days) visits to paediatric emergency department (PED). Retrospective study concerning newborns who presented to PED of Sakarya University Maternity and Paediat...

Medical and Biotech [MESH] Definitions

The event that a FETUS is born alive with heartbeats or RESPIRATION regardless of GESTATIONAL AGE. Such liveborn is called a newborn infant (INFANT, NEWBORN).

Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.

A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).

Diseases existing at birth and often before birth, or that develop during the first month of life (INFANT, NEWBORN, DISEASES), regardless of causation. Of these diseases, those characterized by structural deformities are termed CONGENITAL ABNORMALITIES.

An infant during the first month after birth.

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