Oral Contraceptive (OC) Progestin Dose and Breast Proliferation
Summary
The purpose of this research study is to gain a better understanding of the changes that may occur in the breast when a woman uses an oral contraceptive (birth control pill). Some research indicates that women who use birth control pills with lower amounts of progestin (a hormone in the birth control pill) may have lower breast cell growth than women who use birth control pills with a higher amount of progestin; this research will examine that in detail.
Study Design
Allocation: Randomized, Control: Dose Comparison, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Conditions
Oral Contraceptive
Intervention
Oral Contraceptive: Ortho-Novum® 1/35, Oral Contraceptive: Ovcon Fe®
Location
Los Angeles County Hospital
Los Angelses
California
United States
90033
Status
Completed
Source
USC/Norris Comprehensive Cancer Center
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00972439
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Oral Medicine
A branch of dentistry dealing with diseases of the oral and paraoral structures and the oral management of systemic diseases. (Hall, What is Oral Medicine, Anyway? Clinical Update: National Naval Dental Center, March 1991, p7-8)
Lynestrenol
A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive.
Contraceptives, Oral, Sequential
Drugs administered orally and sequentially for contraceptive purposes.
Ethynodiol Diacetate
A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Desogestrel
A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Clinical Trials
To Compare SH T00658ID Over Ortho Tri-Cyclen Lo (US/Canada)
The objective of the study is to compare the oral contraceptive (OC) SH T00658ID over Ortho Tri-Cyclen Lo administered for 13 cycles to healthy female volunteers between 18 and 50 years of...
Atazanavir and Ritonavir (ATV/RTV) and an Oral Contraceptive in Healthy Females
The purpose of this study is to administer a combined oral contraceptive (ethinyl estradiol and norgestimate) with the HIV treatment of atazanavir and ritonavir to healthy females in order...
The objective of this study is to compare the levels of the hormones norelgestromin, norgestrel, and ethinyl estradiol in the bloodstream of healthy female volunteers administered ORTHO EV...
Oral Contraceptive Interaction Study for GW273225
GW273225 is in development for epilepsy and bipolar disorder and can affect women of child bearing potential. A clear understanding of the potential interaction between oral contraceptive...
OBJECTIVES: I. Evaluate the beneficial effects of leuprolide depot, oral contraceptive therapy, and leuprolide/oral contraceptive therapy in the management of patients with ovarian...
PubMed Articles
The effect of parity and oral contraceptive (OC) use on breast cancer risk differs by cancer subtype as defined by histology. Family history of breast cancer impacts decisions regarding both parity an...
Oral contraceptive use and breast cancer: A prospective study of young women.
BACKGROUND: Previous studies convincingly showed an increase in risk of breast cancer associated with current or recent use of oral contraceptives in the 1960's to 1980's. The relation of contemporary...
BACKGROUND: Oral contraceptive formulations have changed over time, making it relevant to assess the effect of more recent formulations on breast cancer risk. In addition, some studies have found stro...
Contraception choices in women with underlying medical conditions.
Primary care physicians often prescribe contraceptives to women of reproductive age with comorbidities. Novel delivery systems (e.g., contraceptive patch, contraceptive ring, single-rod implantable de...
Abstract Objective: To determine whether OCPs are underutilized in the treatment of acne in women of reproductive age, how use of OCPs compared to use of isotretinoin, and whether adequate use and doc...
