Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation
Summary
The study will evaluate Apitox, pure honeybee venom as a treatment for pain and inflammation of osteoarthritis of the knee.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Osteoarthritis of the Knee
Intervention
honeybee venom (Apitoxin (Korea) Apitox (USA))
Location
Radiant Research Inc.
Pinellas Park
Florida
United States
33781
Status
Completed
Source
Apimeds, Inc.
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00949754
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Osteoarthritis, Knee
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Korea
Former kingdom, located on Korea Peninsula between Sea of Japan and Yellow Sea on east coast of Asia. In 1948, the kingdom ceased and two independent countries were formed, divided by the 38th parallel.
Republic Of Korea
The capital is Seoul. The country, established September 9, 1948, is located on the southern part of the Korean Peninsula. Its northern border is shared with the Democratic People's Republic of Korea.
Knee Injuries
Injuries to the knee or the knee joint.
Knee Prosthesis
Replacement for a knee joint.
Clinical Trials
Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis
The study will identify the efficacy of Apitox, purified honeybee toxin, in 300 patients with diagnosed osteoarthritis of the knee. The subjects will be evaluated for relief of pain using...
Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis
Study wishes to determine if the use of injectable bee venom is a safe and effective treatment for persons with mild to moderate knee Osteoarthritis and would result in decreased report of...
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The purpose of this study is to use better magnetic resonance imaging (MRI) techniques to examine the knee and the bony and soft tissue changes so as to better predict the progression of o...
The purpose of this research study is to investigate the safety and tolerability of OP-1 when it is injected into the knee joint of patients who have osteoarthritis on the knee.
PubMed Articles
Characterization of honeybee venom by MALDI-TOF and nanoESI-QqTOF mass spectrometry.
The aim of the study was to comprehensively characterize different honeybee venom samples applying two complementary mass spectrometry methods. 41 honeybee venom samples of different bee strains, coun...
Safety of hymenoptera venom immunotherapy: a systematic review.
Introduction: The efficacy of venom immunotherapy (VIT) in patients with insect sting allergy is not questioned. However, its safety, especially when honeybee is used, is a matter of concern. Areas co...
Nonpharmacologial and nonsurgical therapies for osteoarthritis: Orthosis, exercises.
Unloading valgus knee braces may be more effective than knee sleeves, to improve pain and disability for medial knee osteoarthritis, but have more adverse effects. A lateral-wedge insole could reduce...
Bilateral total knee replacement in a congenital amputee with bilateral fibular deficiency.
We present the first ever reported case of bilateral total knee replacements in a congenital amputee with bilateral fibular deficiency. A 60year old woman with bilateral fibular hemimelia presented wi...
