DuoTrav APS Versus XALACOM® in Ocular Surface Health
Summary
To demonstrate superiority of DuoTrav APS over XALACOM® in Ocular Surface Health in patients with open angle glaucoma or ocular hypertension.
Study Design
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Conditions
Open Angle Glaucoma
Intervention
DuoTrav APS, Xalacom
Location
Alcon Call Center for Trial Locations
Fort Worth
Texas
United States
76134
Status
Recruiting
Source
Alcon Research
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00912054
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Glaucoma, Open-angle
Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.
Hydrophthalmos
Congenital open-angle glaucoma that results from dysgenesis of the angle structures accompanied by increased intraocular pressure and enlargement of the eye. Treatment is both medical and surgical.
Corneal Endothelial Cell Loss
Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging.
Scattering, Small Angle
Scattering of a beam of electromagnetic or acoustic RADIATION, or particles, at small angles by particles or cavities whose dimensions are many times as large as the wavelength of the radiation or the de Broglie wavelength of the scattered particles. Also know as low angle scattering. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Small angle scattering (SAS) techniques, small angle neutron (SANS), X-ray (SAXS), and light (SALS, or just LS) scattering, are used to characterize objects on a nanoscale.
Glaucoma, Angle-closure
A form of glaucoma in which the intraocular pressure increases because the angle of the anterior chamber is blocked and the aqueous humor cannot drain from the anterior chamber.
Clinical Trials
DuoTrav® Eye Drops As Replacement Therapy Program
To evaluate the effectiveness of DuoTrav Eye Drops in gaining or maintaining control of target Intraocular Pressures (tIOP) in patients diagnosed with, and being treated for, open-angle gl...
A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma
Hypothesis: - H1: Efficacy of Duotrav will be superior to Xalacom at 24 hours post dosing when both medications are given in the morning - H2: A significant proportion...
A Phase IIIb Study of DuoTrav to Treat Glaucoma or Ocular Hypertension
The purpose of this study is to assess patient compliance with DuoTrav versus concomitant administration of Timolol 0.5% plus TRAVATAN in patients with open-angle glaucoma or ocular hypert...
Assess safety and efficacy of transitioning uncontrolled glaucoma patients to DuoTrav from other mono- or adjunctive therapies
A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
The purpose of the study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension
PubMed Articles
PURPOSE: Limb length changes were evaluated after closed- and open-wedge high tibial osteotomies (HTOs) using computer-assisted surgery. M...
Biomarkers in primary open angle glaucoma.
Abstract Glaucoma, a leading cause of blindness worldwide, is currently defined as a disturbance of the structural or functional integrity of the optic nerve that causes characteristic atrophic change...
Background: The aim of this study was to evaluate diagnostic parameters and analysis of their advantages and limitations in early diagnostics of primary open-angle glaucoma (POAG). Cup/disc ratio (C/D...
BACKGOUND: The purpose of this study was to investigate and measure light-dark changes in iris thickness (IT) and anterior chamber angle width in eyes with occludable angles and open angles by using a...
Different types of optic disc shape in patients with advanced open-angle glaucoma.
PURPOSE: To study the characteristics of patients with advanced open-angle glaucoma. METHODS: A hospital-based retrospective study was performed. Advanced glaucoma was defined as visual acuity of 0.3...
