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Content Validation of Quality of Life and Symptom Questionnaires for Pheochromocytoma and Paraganglioma

08:45 EDT 23rd April 2014 | BioPortfolio

Summary

The purpose of this qualitative study is to evaluate the clarity and comprehensiveness of two disease-specific questionnaires, and to evaluate how effective these questionnaires are at assessing the quality of life and symptoms of patients with pheochromocytoma or paraganglioma.

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Conditions

Pheochromocytoma

Location

Oxford Outcomes- Nationwide Recruitment within the US
Bethesda
Maryland
United States
20814

Status

Recruiting

Source

Molecular Insight Pharmaceuticals, Inc.

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

A selective adrenergic alpha-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.

A benzodioxane alpha-adrenergic blocking agent with considerable stimulatory action. It has been used to diagnose PHEOCHROMOCYTOMA and as an antihypertensive agent.

An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)

A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)

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Phase 1-2 Study of Iobenguane (MIBG) I 131 in Patients With Malignant Pheochromocytoma/Paraganglioma

The purpose of this study is to determine whether iobenguane I 131 is safe and effective in patients with malignant pheochromocytoma or paraganglioma.

Specificity of Elevated Plasma EM66 Levels in Pheochromocytoma

Pheochromocytoma or paraganglioma are tumors generating hypertension as a symptom. Different biological tests are currently available to diagnose these tumors. However, they all lack speci...

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Diagnosis and Treatment of Pheochromocytoma

Pheochromocytoma is a tumor of the adrenal gland. This tumor is typically benign (not cancerous) and can be cured by surgical removal. However, pheochromocytomas produce neurohormones ca...

PubMed Articles [59 Associated PubMed Articles listed on BioPortfolio]

Dexmedetomidine induced catecholamine suppression in pheochromocytoma.

Pheochromocytoma is a neuroendocrine tumour of chromaffin cells, though rare but a known cause of paroxysmal hypertension with a triad of headache, diaphoresis and palpitation. The biochemical diagnos...

Evaluation of urinary metanephrines for the diagnosis of pheochromocytoma.

Objective: evaluate the assay of urinary metanephrines in diagnosis of pheochromocytoma (PH) and determine diagnostic cut-off values. methods: this is a retrospective study about 87 patients suspected...

Tetralogy of Fallot with pheochromocytoma: An unusual therapeutic challenge.

An adult with unoperated tetralogy of Fallot diagnosed simultaneously with pheochromocytoma is extremely rare. This poses obvious diagnostic and therapeutic challenges. A 29-year-old woman with these...

A case report of reactive hypoglycemia in a patient with pheochromocytoma and it's review of literature.

Pheochromocytoma, a tumor characterized by catecholamine excess, is usually associated with impaired glucose tolerance. Hypoglycemia may occur after the abrupt withdrawal of catecholamines in the post...

Pheochromocytoma can be an insidious disease.

Pheochromocytoma is a tumor of the chromaffin tissue, originating from the suprarenal medulla and secreting cathecolamines, adrenalin and noradrenalin. Because the symptoms of this rare disease may de...

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